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Microbiology 2 > Lecture 13: Reoviruses and rotaviruses > Flashcards

Lecture 13: Reoviruses and rotaviruses Flashcards

1
Q

Answer kahoot

A

Bovine papillomavirus

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2
Q

answer kahoot

A

double stranded DNA and single stranded RNA

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3
Q

What are the two types of reoviruses

A

orbiviruses and rotaviruses

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4
Q

what type of virus is epizootic hemorrhagic dz

A

reovirus, orbivirus

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5
Q

what are some signs of epizootic hemorrhagic disease

A

ulcers on tongue, petechiae hemorrhage along esophagus

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6
Q

t or f: epizootic hemorrhagic disease and bluetongue are reportable diseases

A

true

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7
Q

orbiviruses are __dsRNA

A

segmented

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8
Q

what is significance of segmented dsRNA

A

can take segments from multiple strains of virus in host and produce a completely new virus

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9
Q

what is the vector for orbiviruses

A

culicoides

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10
Q

what is the geographic distribution for orbiviruses

A

tropical and subtropical

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11
Q

how do reoviridae viruses replicate

A
  1. Attach to host receptors and endocytosis
  2. Partial uncoating in endolysozomes
  3. Early transcription of genome by viral pol within viral particle (still in cytoplasm) dsRNA—>mRNA
  4. MRNA segmented translation
  5. Viral protein/RNA aggregation and encapsulation
  6. Release of mature virions with cell death
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12
Q

what is the significance of reovirdae viruses doing partial uncoating during replication

A

hide from innate immune system because dsRNA not in healthy cells

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13
Q

where does transcription of reovirdae viruses like EHD take place

A

within viral particle in cytoplasm

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14
Q

how are EHD and BTC distinguished

A

subtle antigenic differences

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15
Q

t or F: African horse sickness is in united states

A

false

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16
Q

what bluetongue viruses are endemic to North America

A

BVT-2,10,11,13,17

17
Q

what BTV are non-endemic to US and considered FAD

A

BTV-8, 4, 1, 14

18
Q

t or f: EHD is endemic in North America

19
Q

what is orbiviruses pathogenesis

A
  1. Exposure to vector
  2. Primary viremia—> bone marrow
  3. Secondary viremia—> endothelial cells
  4. Edema, hemorrhage, thrombosis, DIC
20
Q

what are some clinical signs of orbiviruses (BTV, EHD)

A
  1. Fever >106.0
  2. Oronasal discharge, hypersalivation, oral necrosis
  3. Coronary band damage, lameness
  4. Sudden unexplained death (EHD)
21
Q

Called out to sheep farm for sheep who suddenly died, presented with oronasal discharge, ulcers. What is your concern/dx

22
Q

how do you dx orbiviruses

A
  1. Insect vectors present (culicoides)
  2. AGID
  3. ELISA
23
Q

answer kahoot

A

mature enterocytes

24
Q

what is pathogenesis of rotaviruses

A
  1. Feco-oral transmission
  2. GI passage—> enterocytes
  3. Loss of mature enterocytes at tips of villus
  4. Bacterial proliferation
  5. Malabsorptive and secretory diarrhea
25
what do rotaviruses target
tips of villi/mature enterocytes
26
what are some clinical signs of rotaviruses
Last 3-4d, non-bloody +/- watery diarrhea
27
how do you dx rotaviruses
Serogroup A ELISA/latex agglutination
28
how do you prevent rotaviruses
1. Oral vaccine 2. Clean environment 3. Colostrum- maternal Ab’s
29
what is tx for rotaviruses
supportive fluids, management of concurrent infections
30
what type of virus is infectious bursal disease virus
birnavirus
31
what are some necropsy findings consistent with infectious bursal disease virus
1. Ecchymotic hemorrhage in pectoral muscles 2. Enlarged bursa fabricius, edema
32
from chicken- what concern/dx
Infectious bursal disease virus
33
where does brnaviridae (IBDV) dsRNA transcription occur
within virion
34
what is tx for infectious bursal disease virus
1. Depop/repop/all in all out 2. Vaccination 3. Husbandry and biosecurity
35
what cells does IBDV target and what is result
B cells, causing immunosuppression
36
how do birnaviruses and other dsRNA viruses avoid detection by immune system
early replication occurs in vision to avoid exposing dsRNA
37
how is IBDV dx
ELISA +/- VI, RT-PCR +/- genome sequencing
38
answer kahoot
Within viral particle itself

Microbiology 2 (27 decks)

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