Lecture 12: Parvo, Circo Flashcards
Paroviruses depend on __cells for replication
rapidly dividing cells
parvoviruses lack __
DNA polymerase
how do parvoviruses replicate
rolling-hairpin (self priming) mechanism
what are some important parvoviruses
- Feline panluekopenia
- Canine parvovirus (1, 2a/b/c)
- Porcine parvovirus
- Equine parvovirus
What is pathogenesis of parvovirus in small animals
- Fecal oral/ aerosol transmission
- Local LN replication
- Disseminated viremia- target organs
- bone marrow
- intestinal crypt cells (villus atrophy)
- LN and spleen
what organs are targeted by parvo
- Bone marrow
- Intestinal crypt cells (villus atrophy)
- LN and spleen
what are some clinical signs of parvo in small animals
vomiting, anorexia, bloody diarrhea, anemia, leukopenia, hypoglycemia, hypoproteinemia
how do you dx parvo in small animals
- Snap ELISA-Ag
- Hemagglutination inhibition- Ab
the parvo snap test evaluates for presence of parvo viral __
antigen
how do you tx parvo
- Palliative
- Fluids, blood/plasma transfusion
- Antibiotics
- Anti-emetics
- Gastroprotectants
Where does pre-natal parvo viral infection in cats target
developing granular layer in the cerebellum
theilers disease aka __
equine serum hepatitis
theilers disease is transmitted via
equine serum derived products (tetanus/botulinum antitoxin, plasma transfusion)
what are some clinical signs of theilers dz
acute, fulminant liver failure
how do you test and prevent theilers dz
PCR testing and screening of blood products
what are some clinical signs of porcine parvovirus
SMEDI: stillbirths, mummification, embryonic deaths, infertility
What caused this in pigs
Porcine parvovirus
how do you prevent and tx porcine parvo
- Expose susceptible breeding animals to older animals
- Vaccinate 2-4 weeks prior to breeding
What are 3 examples of circoviruses
- Post weaning multisystemic wasting syndrome
- Chicken anemia virus
- Psittacine beak and feather disease
How do circoviruses replicate
“rolling circle”
What is the target of post-weaning multisystemic wasting syndrome
rapidly dividing cells (lymphocytic)
post-weaning multisystemic wasting syndrome is mild as a __ agent, __ infection common
single, co-infection
what is tx and control for post-weaning multisystemic wasting syndrome
proper husbandry, biosecurity, all in, all out, vaccines
What does chicken anemia virus target
early thymic T cells
what does psittacine beak and feather disease target
lymphocytes, feather follicles and beak/claw growth matrices
