Lecture 19: Flaviviruses Flashcards
answer kahoot
peyers patches
answer kahoot
porcine parvovirus
what is the morbidity and mortality differences between BVD and mucosal disease of BVD
BVD: high morbidity, low mortality
MD: low morbidity, high mortality
what is the most economically important viral disease of cattle worldwide
BVDV
BVDV 1 and 2 have __ and __ forms
cytopathic and non-cytopathic forms
who does border disease virus infect and what does it cause
sheep- odd hair coat at birth, frail neurologic
what are the two clinical forms of BVDV
- Conventional
- Mucosal disease
what are the two variants of BVDV
- Cytopathic
- Non-cytopathic
persistently infected animals with BVDV are infected __ and have __virus that later mutates into __
in utero, non-cytopathic virus, mutates into cytopathic virus
is conventional BVD cytopathic or non-cytopathic
non-cytopathic
what occurs if pregnant cow infected with BVD day 0-30 gestation
embryonic death, apparent infertility
what occurs if pregnant cow infected with BVD day 30-150 gestation
abortion, congenital anomalies
what occurs if pregnant cow infected with BVD days 30-90 gestation
persistent infection (non-cytopathic strain)
what occurs if pregnant cow infected with BVD >150 gestation
no adverse effects
what is pathogenesis of BVDV conventional form
- Aerosol/ fecal transmission from persistently infected cattle
- Oronasal exposure and replication in mucosa
- Viremia- free or leukocyte associated
- Immunosuppression: Lympho/leuko/ thrombocytopenia
- Targets: enterocytes and lymphoid centers in gut, spleen, tonsils
Animals exposed in utero days 30-90 gestation get __infection of BVDV before __, after __
persistent BVDV, before immunocompetence, after neural development
t or f: persistently infected calves with BVDV form antibodies
false
what is the primary source of infection in herds for BVDV
persistently infected cows
mucosal disease of BVDV is mutation from __strain to __ strain
non-cytopathic to cytopathic strain
what is the mutation that occurs to go from non-cytopathic BVDV to cytopathic
NS2/NS3–>NS3
what is target of cytopathic strain of BVDV
GALT tissues/peyers patches
how can you dx BVDV in persistently infected calves
ear notch antigen capture ELISA (ACE)
how can you dx conventional infection with BVDV
FA on affected tissues, serology, PCR (unlikely ACE +)
how does ear notch test work for BVDV
- Primary antibody bound to plate
- Ag from sample binds primary antibody
- Secondary antibody binds antigen with color change
