lecture 24 analgesia

Question 1

local anaesthetics are

Answer 1

esters and amides

Question 2

common intravenous general anaethetic

Answer 2

propofol

Question 3

common inhaled egeneral anaesthetic

Answer 3

isoflurine

Question 4

how is potency affected

Answer 4

how lipid soluble they are

Question 5

three principals of anaesthetics

Answer 5

loss of reflex
unconscious
analgesia

Question 6

why do you want to stop the reflexes

Answer 6

so you can put tubes down

Question 7

where is the RAS

Answer 7

brainstem

Question 8

what does RAS control

Answer 8

sleep/wake

Question 9

barbituates work on

Answer 9

GABA receptor

Question 10

how do inhaled drugs affect the GABA receptor

Answer 10

change the phospholipid bilayer around it

Question 11

volatile onset in general

Answer 11

slow

Question 12

volatile onset in children

Answer 12

fast

Question 13

volatile onset in COPD

Answer 13

slow

Question 14

what is volatile

Answer 14

close to boiling point

Question 15

common volatile drugs

Answer 15

NO, isoflurane and sevoflurane

Question 16

volatile metabolism

Answer 16

none

Question 17

volatile side effects

Answer 17

depression of cardiovascular and respiratory

Question 18

volatile abnormal reaction

Answer 18

malignant hyperpyrexia and bone marrow suppression (in staff also)

Question 19

Intravenous onset in general

Answer 19

rapid

Question 20

how long does it take for intravenous to work

Answer 20

one arm heart brain cycle

Question 21

intravenous examples

Answer 21

propofol, Thiopental, and ketamine

Question 22

intravenous metabolism

Answer 22

in the liver

Question 23

intravenous abnormal reaction

Answer 23

anaphylaxis

Question 24

local anaesthetics block

Answer 24

sodium channels

Question 25

how do local anaesthetics stop depolarisation

Answer 25

stop the influx of sodium

Question 26

chemical of local aneasthetics

Answer 26

alkaline

Question 27

what tissue cant local anesthetics work in

Answer 27

acidic

Question 28

example of a tissue local anaesthetics cant work on

Answer 28

absess

Question 29

why may a local anaesthetic take longer to work

Answer 29

if the nerve is myelinated

Question 30

first group of nerves to be anaesthatised under local

Answer 30

C fibres

Question 31

what does the patiet first expreience with local

Answer 31

tingling | dryness

Question 32

why do the patients get the first experience with local

Answer 32

vasodilation

Question 33

second fibres local affacts

Answer 33

C again

Question 34

second experience by the patient

Answer 34

touch and pain

Question 35

last fibers the local affects

Answer 35

A delta

Question 36

last experience with local

Answer 36

loss of motor function

Question 37

describe anaesthesia of the brain

Answer 37

stimulatory period: fit | unconsciousness

Question 38

what chemical roperty should drugs have to stop them affecting the brain

Answer 38

heavier than water

Question 39

neuromuscular blocking drugs are divided into

Answer 39

antagonist and agonist

Question 40

describe neuromuscular blocking drugs atagonists

Answer 40

non depolarising | competative

Question 41

describe neuromuscular blocking drugs agonists

Answer 41

depolarising | non competative

Question 42

example of neuromuscular blocking drugs antagonist

Answer 42

atracurium

Question 43

eample of neuromuscular blocking drugs agonist

Answer 43

suxamethonium

Question 44

Anticholinesterases reverse

Answer 44

non depolarising

Question 45

Suxamethonium

Answer 45

depolarising muscle relaxant

Question 46

Suxamethonium molecule

Answer 46

two acetylecholines stuck together

Question 47

Suxamethonium binds to

Answer 47

acetylecholine receptor

Question 48

MOA of Suxamethonium

Answer 48

binds to receptor causes firing until the nerve is exhausted not broken down

Question 49

how do you know when you give Suxamethonium

Answer 49

twithcing then relaxation

Question 50

Suxamethonium wears of after

Answer 50

5-10 mins

Question 51

where is Suxamethonium broken down

Answer 51

plasma

Question 52

rare side effect of Suxamethonium

Answer 52

Suxamethonium apnoea - people dont have the enzymes to break it down

Question 53

name a drug that inhibits acetylecholine esterase

Answer 53

pyridostigmine