lecture 10 joint disease Flashcards
5 good words to describe RA
chronic, symmetrical, inflammation, deforming and polyarthritis
onset of RA
slow
where RA
small joints of hands
symmetrical
when RA
early morning
primary site of inflammation for RA
synovium cells lining the joint
drugs to block TNF alpha
infliximab, adlimumab and entanercept
affect of TNF of vasculature
Increases vascular endothelial growth factor
TNF and the liver
hepatocytes increase C reactive protein
TNF and skin
keratin hyperproliferation
TNF and cartilage
MMP activation which is an enzyme which causes cartilage damage
most common cause of death in RA patients
myocardial infarction
what happens if the RA goes unchecked
premature atherosclerosis
sarcopenia
weakening of muscles
pain worse after activity is
osteoarthritis
osteoarthritis pain where
weight baring
osteoarthritis risk factors
age
female
genetics
obesity
gout usually affects
men
what is gout
soft tissue deposits of uric acid
when would a woman get gout
after menopause
who is gout more common in
people with kidney disease because they cant excrete uric acid
what is broken down to produce uric acid
purines
what enzyme produces uric acid
xanthine oxidase
what drugs can you use to block xanthine oxidase
allopurinol and febuxostat
what promotes brwaking down purines that may predispose you to gout
chemo
