Lecture 18 11/9/23 Flashcards
What are the general characteristics of Chlamydia spp.?
-obligate intracellular
-parasites of epithelial cells
-susceptible to tetracycline
-dimorphic life cycle
-energy parasites/consume host ATP
Which Chlamydia spp. is known for causing zoonotic infections?
C. psittaci
Which Chlamydia spp. cause disease in humans?
-C. trachomatis (human chlamydiosis
-C. pneumonia
What are the two life cycle stages of Chlamydia spp.?
-intracellular replicating form
-extracellular non-replicating form
What are the characteristics of elementary bodies?
-infectious stage of Chlamydia spp.
-can survive outside the host
What are the characteristics of C. psittaci?
-causes avian chlamydiosis
-BSL-3 pathogen
-zoonotic
-reportable
What is the pathogenesis of C. psittaci?
-elementary bodies shed in carriers’ feces
-replicate in epithelial and phagocytic cells after inhalation
-cause septicemic, multi-organ infection
Which lesions are associated with C. psittaci?
basophilic intracytoplasmic bacterial inclusions
How are Chlamydia spp. diagnosed?
-microscopic detection
-culture in embryonated eggs, tissue, or animals
-serology
-PCR
How are Chlamydia sp. treated?
tetracycline
How are Chlamydia sp. controlled?
isolation and quarantine procedures
What disease manifestations are caused by Chlamydia abortus in ruminants?
-placentitis
-abortion
What disease manifestations are caused by Chlamydia pecorum?
-polyarthritis in lambs and calves
-sporadic bovine encephalomyelitis in young cattle
What are the characteristics of Chlamydia felis?
-causes feline pneumonitis
-common signs are conjunctivitis and rhinitis
What are the characteristics of Coxiella burnetii?
-causes Q fever
-obligate intracellular
-causes subclinical infection, abortion, and placentitis
-highly persistent in environment
-has resistant endospore-like form
-highly zoonotic
How is Coxiella burnetii diagnosed?
-serology
-direct demonstration
-culture in cell lines
-PCR
Which antimicrobials can be used to treat C. burnetii?
-tetracycline
-fluoroquinolones
How can C. burnetii be controlled and prevented?
-hygiene
-education
-early diagnosis
-vaccination
Which order Rickettsiales members are pathogens of dogs and cats?
-Ehrlichia canis
-E. chaffeensis
-E. ewingii
-Anaplasma phagocytophilum
-A. platys
-Neorickettsia helmintoeca
-N. risticii
-Rickettsia rickettsii
What are the characteristics of Rickettsia?
-arthropod-transmitted
-parasites of blood cells or endothelial cells
-gram-neg. coccobacilli
-cause persistent infections
-obligate intracellular
-rodents/small mammals are reservoirs
What are the two groups of Rickettsia?
-typhus group
-spotted fever group