Lect 11 - CNS (Cranial Meninges and Circulation) Flashcards

1
Q

What is the Dura Mater

A

The outer layer of The Cranial Meninges

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2
Q

What are the two layers of the Dura Mater

A

Periosteal Cranial Dura (Outer)

Meaningeal Cranial Dura (Inner)

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3
Q

The space between the two Dura Mater layers contains?

A

Dural Sinuses (Large Veins)

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4
Q

In the Dura Mater what do the Dural Septae separate and form

A

Falx Cerebri
Tentorium Cerebelli
Falx Cerebelli
Diaphragma Sellae

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5
Q

What is the Falx Cerebri? What does it contain?

A

A meningeal layer that covers the brain, extends into the longitudinal fissure

Superior Sagittal Sinus
Inferior Sagittal Sinu

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6
Q

The anterior portion of the Falx cerebri attaches to

A

Crista Galli

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7
Q

The posterior portion of the Falx cerebri attaches to

A

Tentorium cerebelli

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8
Q

What is the Tentorium Cerebelli

A

Separates cerebellar hemisphere with cerebral hemisphere
Occipital lobe of cerebrum and cerebellum
are separated

Contains Transverse Sinus

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9
Q

What is the Falx Cerebelli

A

Contains the Occipital Sinu
Separates the Cerebellar Hemispheres

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10
Q

What is the Diaphragma Sellae

A

Anchors Dura Mater to Sphenoid Bone
Encases Pituitary Gland (Separates it from the bone)

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11
Q

What are Dural Venous Sinuses

A

Channels in between Dura Mater layers

Act like veins
Contains blood
Receive some CSF

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12
Q

Examples of Dural Venous Sinuses

A

Superior Sagittal Sinus
Inferior Sagittal Sinus
Transverse Sinus

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13
Q

Superior Sagittal Sinus

A

Superior Border of Falx Cerebri

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14
Q

Inferior Sagittal Sinus

A

Inferior Border of Falx Cerebri

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15
Q

Transverse Sinus

A

Courses laterally with the tentorium cerebelli

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16
Q

What is the Arachnoid Mater

A

The middle layer of The Cranial Meninges

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17
Q

What does the Arachnoid Mater contain

A

Arachnoid Granulations
Subdural Space
Subarachnoid Space
Trabeculae

18
Q

Arachnoid Mater (Arachnoid Granulations)

A

Villi of the Arachnoid Mater

Cerebral Spinal Fluid can flow into these to enter venous circulation

19
Q

Arachnoid Mater (Subdural Space)

A

The space between the arachnoid mater and meningeal cranial dura

20
Q

Arachnoid Mater (Subarachnoid Space)

A

Space deep to the arachnoid mater

21
Q

Arachnoid Mater (Traberculae)

A

Collagenous Fibers, Weblike material that underlines the arachnoid layer

Anchor cerebral blood vessels

22
Q

What is the Pia Mater

A

Inner Cranial Meninges Layer

Attached to the surface of the brain
Anchored by astrocytes
Anchors large blood vessels of the cerebrum

23
Q

How does the blood brain barrier work?

A

Endothelial cells that are connected by tight junctions prevent the passage of water soluble material

24
Q

What can pass the blood brain barrier

A

Lipid-Soluble Material can pass from blood to cells in the brain/spinal cord

Water-Soluble can only pass through specific transport mechanisms

25
Q

What four regions is the BBB different than the rest of the brain

A

Hypothalamus
Pineal Gland Capillaries
Choroid Plexus Capillaries
Pituitary Gland Capillaries

26
Q

What makes the Hypothalamus different (BBB)

A

Increased permeability for diffusion of hormones

27
Q

What makes the Pineal Gland Capillaries different (BBB)

A

Very permeable for pineal secretions

28
Q

What makes the Choroid Plexus Capillaries different (BBB)

A

No tight junctions

Ependymal Cells form blood-CSF barrier
By producing Cerebrospinal Fluid

29
Q

What makes the Pituitary Gland Capillaries different (BBB)

A

Permeable for hormone release

30
Q

What larger molecules do neurons need? How does it enter the brain?

A

Glucose, endothelial cells of BBB will constantly transport glucose from the blood to neurons
(Blood concentration does not matter)

31
Q

Brain and Glycine

A

Glycine needs to be low in the brain, allowing for active transport to blood

32
Q

Cerebrospinal Fluid Function

A

Prevents neural tissue from touching bone

Provides support for brain (Cushion)

Transport nutrients to CNS
Transport waste away from CNS

33
Q

CSF Appearance and Content

A

Colourless Plasma
Few cells and low protein content

34
Q

How is CSF formed

A

Ependymal Cells of the Choroid Plexus produce CSF by removing water from blood and releasing it as CSF

35
Q

Ependymal Cells

A

Directly transports nutrients into CNS
Directly transports waste away from CNS

Produces Cerebrospinal Fluid

36
Q

Choroid Plexus

A

Contains Ependymal Cells which produces CSF and controls CSF function

37
Q

What is the pathway of CSF

A

CSF is produced in Choroid Plexus of the Lateral Ventricle
–> Flows through interventricular foramen
–> Flows into the third ventricle
–> Flows into cerebral aqueduct of the midbrain
–> Flows into the fourth ventricle
–> Through the Lateral Aperture and Median Aperture

38
Q

Where does CSF end up

A

Most flows into subarachnoid space
–> a small amount enters the central canal of the spinal cord

Flows around the brain and spinal cord
–> eventually enters arachnoid granulations
–> ending up in circulation

39
Q

What structures have Choroid Plexus

A

All ventricles have them

Most specifically roof of 3rd and 4th ventricle

40
Q

Why are neurons dependent on delivery

A

High energy demanding BUT do not have any energy reserves (No myoglobin)

If blood supply is interrupted irreversible damage can occur
As such blood vessels (specifically gray matter) are arranged in a dense meshwork