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Structures: Part Deux > LEC35: Reproductive Tract II > Flashcards

LEC35: Reproductive Tract II Flashcards

0
Q

what partitions cloaca, and what does it partition it into?

A

urorectal septum

posterior region: rectum

anterior region: bladder

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1
Q

when are genitalia undifferentiated

A

4-7 weeks

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2
Q

what membranes form from cloacal partitioning?

A

urorectal septum

creates:

anterior: urogenital membrane
posterior: anal membrane

at 6 weeks!

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3
Q

when and how does the urethral plate form?

A

development of male external genitalia

endodermal cells proliferate, fold upon itself > urethral plate

2 edges of plate meet, ectoderm fuse, closing urethra inside penis

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4
Q

what forms spongy urethra area?

A

urogenital folds

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5
Q

how does penile (median) raphe form?

A

surface ectoderm of urethral plate meet, fuse as line down ventral side of penis

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6
Q

how does scrotal raphe get created?

A

labioscrotal swellings come together

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7
Q

what is urethral epithelium made of?

A

both spongy urethra and ectoderm; surrounded by connective tissue

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8
Q

which part of cloaca does spongy urethra come from?

A

distal part

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9
Q

what is meant by the urethra’s dual origin?

A

canalizing betweeen spongy urethra (endoderm) and glandular part of spongy urethra (ectoderm) forms urethra urethral orifice at tip

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10
Q

what does prepuce form from and when

A

at tip of foreskin middle ectoderm cells die, form cleft week 12

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11
Q

what are the 2 penile rathes, where do they come from?

A

labio-scrotal fusion > scrotal rathe urethral folds fusion > penile rathe

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12
Q

where do labio scrotal folds first fuse?

A

dorsally/posteriorly

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13
Q

what forms labia minora

A

unfused urogenital folds

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14
Q

what forms labia majora

A

unfused labioscrotal folds

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15
Q

what produces estrogens > female genitalia development?

A

mostly placenta, some from fetal ovaries also

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16
Q

where is clitoris nestled

A

between labio-scrotal swellings

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17
Q

what is the hymen

A

tissue that hasn’t canalized with the outside; thin membrane of tissue remains; breaks either at first intercourse or spontaneously

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18
Q

what are the parts of the labia majora that first form?

A

posterior fusion > posterior commissure anterior fusion > anterior commissure middle remains open > labia majora

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19
Q

homologous structures of urogenital sinus

A

male: bladder, urethra (part), prostatic utricle, prostate, bulbourethral glands female: bladder, urethra, vagina, para/urethral glands, bartholins

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20
Q

homologous structures from genital tubercle

A

male: penis female: clitoris

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21
Q

homologous structures from urogenital folds

A

male: ventral penis female: labia minora

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22
Q

homologous structures from labioscrotal folds

A

male: scrotum female: labia majora

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23
Q

typical sexual differentiation def’n

A

external and internal genitalia consistent with sex chromosome content

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24
errors in sex determination and differentiation def'n
disorders of sexual development, incongruence between external genitalia, internal genitalia, sex chromosome content
25
ovotestis
both ovarian and testicular tissue present, either in same or opposite gonads majority 46XX, others 46XX/46XY or 46XY ovotestis nonfunctional - no egg or sperm produced ambiguous genitalia- clitoral enlargement/penile underdevelopment indistinguishable at birth causes poor understood, very rare
26
why might 46XX individual manifest/what do you see?
internal genitalia not different, external genitalia virilization due to exposure of female fetus to excess androgens
27
CAH
congenital adrenal hyperplasia cause- overexposure to androgens occurs b/c steroid hormones from adrenal gland, cholesterol based hormones metabolized - 12 hydroxylase precursors shunted to produce excess testosterone even in female who's missing 12 hydroxylase
28
how to treat CAH in known carrier
give pt high doses of steroids that overcome block in pathway, prevent masculinization of female penis
29
how does 46XY individual appear
male with feminized genitalia; opp of CAH variable external/internal genitalia due to inadequate testosterone, MIS production by fetal testes can have normal or very rudimentary testes 5 alpha reductase deficiency \> many diff manifestations from this
30
androgen insensitivity syndrome
aka testicular feminization - normal-appearing females 46XY normal hormone produce, but cell surface receptors don't receive testosterone correctly - defect in androgen receptor female external genitalia; blind-ending vagina; absent/rudimentary uterus - vaginal plate doesn't break down
31
hypospadias incidence, cause
incidence: 1/300 inadequate production of androgens and/or inadequate receptors \> failure of canalization of ectodermal cord and/or failure of fusion of urogenital folds \> incomplete spongy urethra forms most commonly, distal end of urethra, under urethral orifice- see opening in glans of penis
32
agenesis of external genitalia cause, presentation
very rare urethra opens into perineum near anus- no genital tubercle develops congenital absence of clitoris/penis
33
different causes of anomalies of uterus and vagina
1) incomplete fusion of paramesonephric ducts 2) incomplete development of a paramesnophric duct 3) incomplete canalization of vaginal plate to form vagina
34
uterus didelphys
incomplete fusion of distal/inferior part of paramesonephric duct
35
bicornuate uterus
incomplete fusion of upper part of paramesonephric duct; duplication only of superior part of body of uterus
36
bicornate uterus with rudimentary horn
unequal incomplete fusion- more rudimentary horn on 1 side than the other, 1 short and 1 long portion, pregnancy usu forms in longer portion hematocolpos - no communication between inside and outside
37
hematocolpos
no communication between inside and outside in bicornate uterus w/ rudimentary horn when woman menstruates, blood from endometrium and sloughs off starts to accumulate inside uterine cavity b/c has nowhere to go blood collects behind cervix very painful
38
septate uterus
abnormal fusion of septum - external uterus appears normal, internal septum present though one cause for recurrent miscarriages, but fixable very common!
39
unicornuate uterus
results from failure of 1 paramesonephric duct to develop, have only 1 half of uterus
40
why would vaginal atresia occur? common?
absence of vagina/uterus very rare - 1/80,000 failure of endoderm and ectoderm to fuse, failure of sinovaginal bulbs to develop and form vaginal plate, so get no canalization of vaginal plate, blockage of vagina
41
what do inguinal canals provide
pathway for descent of testes through anterior abdominal wall, into scrotum
42
gubernaculum
long connective tissue strand connecting gonad-labioscrotal swellings of scrotum pulls testes down into scrotum, through inguinal canal
43
what does inguinal canal form from
evagination of peritoneum ventral to gubernaculum
44
what forms coverings of spermatic cord/testes
layers of tissue from abdominal wall that get pulled down as testes descent into scrotum via gubernaculum pulling
45
what does gubernaculum become
tiny strand of tissue, anchoring down scrotum remains to scrotal sac
46
where do 2 inguinal canal rings form from
deep inguinal ring: external oblique m. superficial inguinal ring: transversalis fascia
47
what enables testes to pass through deep inguinal rings?
atrophy of paramesonephric ducts
48
what guides testes through inguinal canal?
processus vaginalis
49
what happens as testes descent?
enlarge, mesonephric kidneys atrophy, paramesonephric ducts atrophy, processus vaginalis guides thru canal
50
what helps testes descned through canal
increase in intra-abdominal pressure from enlarging abdominal organs
51
when do testes descend
26 weeks
52
where do testes move from/to
"relative movement" from posterior abdominal \> inguinal canal \> scrotum
53
do all newborns have descended testes?
no, 97% spontaneous descent no longer occurs after 1 yr
54
what does transversalis fascia become in testes coverings?
internal spermatic fascia
55
what does internal oblique m. become in testes coverings?
cremasteric m./fascia
56
what does external oblique m. become in testes coverings?
external spermatic fascia
57
what happens to processus vaginalis after testes descent
during perinatal pd, remnant of stalk of processus vaginalis obliterates tunica vaginalis remains as isolated peritoneal sac around testes
58
cryptorchidism
undescended testes anywhere along pathway of descent caused by androgen deficiency in fetal testes if remain undescended, increased risk of sterility, testicular cancer
59
ectopic testes cause
gubernaculum passing to abnormal location
60
congenital inguinal hernia
failure of complete closure btwn tunica vaginalis & peritoneal cavity persistent processus vaginalis remains
61
what does gubernaculum become in females
ovarian ligament, connects ovary-uterus, and round ligament
62
where does gubernaculum pull down into in female
labium majora, to labial-scrotal swellings
63
hydrocele
abdominal end of processus vaginalis has small opening, allows peritoneal fluid to pass through

Structures: Part Deux (36 decks)

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