Genital Development: Summary (LEC35) Flashcards
where do primordial germ cells go
migrate from wall of yolk sac > developing gonads
when is indifferent stage of development
til 7 weeks
when are external genitalia distinguishable
after 12 weeks
what determines gonadal sex?
TDF on y-chromosome
what is necessary for mesonephric ducts to develop
leydig cells, > testosterone
what inhibits development of paramesonephric ducts
Sertoli cells > MIS
what stimulates normal ovarian development
no Y and 2 XX’s
what becomes uterus and tubes?
paramesonephric ducts
what does vagina form from
vaginal plate, from urogenital sinus
what do indifferent external genitalia become
clitoris, labia
what are male/female DSDs caused by, examples?
male- inadequate androgens or tissue insensitivity
female- CAH causing excess androgens
why do most female genital tract anomalies occur
incomplete fusion of paramesonephric ducts
what does abnormal testicular descent result in
cryptorchidism, ectopic testes
what does persistence of processus vaginalis result in
congenital inguinal hernia, hydrocele
what causes hypospadias
failure of fusion of urogenital folds
