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Fungal/Virology > LEC 18 - Distemper + PI3 > Flashcards

LEC 18 - Distemper + PI3 Flashcards

1
Q

What is seen upon PE in a dog with distemper?

A

Blepharendema + blepharitis

Preputial edema

Fever

Enlarged LN

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2
Q

What is the diagnostic plan for a dog with distemper?

A

CBC

Chemistry panel

U/A

LN aspirattion

Chest rads

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3
Q

What is seen increased on a CBC in a dog with distemper?

A

INcrease Neutrophils

Increased monocytes

Increased nucleated cells

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4
Q

What is the general thing seen upon cytology of a dog with distemper?

A

Supprative inflammation

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5
Q

What are the differential diagnosis for a dog with distemper?

A

Autoimmune

Infectious - Staph + Pseudomonas

Leshmania

Rickettsia

Idiopathic

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6
Q

What testing can be done for distemper?

A

Swab

Serology

Culture/Sensitivity

Anti-nuclear testing (Autoimmune)

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7
Q

What is the genomic structure of CDV?

A

ssRNA (-)

Enveloped

No segments

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8
Q

What does it mean when an ssRNA virus is not segmented?

A

No recombination can occur

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9
Q

Where does CDV replicate in the cell?

A

Cytoplasm

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10
Q

What are the other distempers in the environment?

A

Measles

Rinderpest

Phocine distemper virus

Cetacean morbilliviurs

Nipah virus

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11
Q

What species are infected by CDV?

A

Canidae

Felidae

Ursidae

Mustilidae

Procyonidae

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12
Q

What is seen in big cats with CDV infections?

A

Grand mal seizures

Myoclonus

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13
Q

How is it thought that CDV was introduced into the serengeti?

A

Via Domestic dogs

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14
Q

Where does CDV enter the body?

A

Respiratory epithelieum

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15
Q

Where does initial CDV replication occur?

A

Epithelial Macrophages

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16
Q

How does CDV move throughout the body?

A

Migrate to draining LN

Primary viremia

Secondary viremia

CNS penetration

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17
Q

What occurs with primary viremia in CDV?

A

Replication in lymph organs

Fever

Lymphopenia

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18
Q

What occurs with secondary viremia in CDV?

A

Disseminates to epithelial tissues

GI + UT + Respiratory

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19
Q

Where does CDV tend to infect in the brain?

A

Grey matter

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20
Q

How does CDV shed?

A

In all body secretions

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21
Q

Where does CDV persist in the body?

A

Uveal tissues

Neurons

INtegument

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22
Q

What is seen with CDV upper respiratory infections?

A

Mucopurulent discharge

Dry/productive cough

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23
Q

What is seen with lower respiratory tract infections with CDV?

A

Interstital lung pattern - early on

alveolar with secondary bronchopneumonia - late

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24
Q

What symptoms are seen when grey matter is infected with CDV?

A

Seizures

Stupor

Atazia

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25
Q

What symptoms are seen when the white matter is infected wioth CDV?

A

Multifocal, cerebellar-vestibular ataxia

UMN/GP signs

26
Q

What are the clincal signs seen with CDV that are not respiratory or neuro?

A

Enamel hypoplasia

Hypertrophic keratropathy

Metaphyseal osteosclerosis

27
Q

What is seen grossly with a CDV infection?

A

Thymic atrophy

Bronchopneumonia

ENteritis

Lymphoid necrosis

Intersitial pneumonia

28
Q

What is seen histologically with CDV infection?

A

Both cytoplasmic/IN inclusion bodies

Esoinophilic

29
Q

What is the tranimission route of CDV?

A

Aerosol - body fluids (respiratory + urine)

Fecal/oral

30
Q

What are the clincal signs in puppies that were infected with CDV transplacentally?

A

Enamel hypoplasia

Cardiomyopathy

Increased risk of CNS

31
Q

How long does it take to see signs if a puppy was infected with CDV transplacentally?

A

4 to 6 weeks of age

32
Q

What happens in old dogs that have been previously infected with CDV?

A

Old Dog Encephalitis

33
Q

What five tests can be done to test for CDV?

A

FA

rt-PCR

Blood smear

Antibody tests

Virus isolation

34
Q

When is viral isolation good to use for CDV diagnosis?

A

Neonates,

Determines vaccinal vs. natural infection

35
Q

Which CDV test is the most sensitive?

A

rt-PCR

36
Q

Which CDV test is the go to test first?

A

FA

37
Q

What cell types are inclusion bodies seen in?

A

Macrophages

RBC’s

38
Q

What does CDV FA testing require?

A

Active infection

39
Q

What is used for a CDV FA?

A

Conjunctival swab

Preputial swab

Impression of - Brain + Bladder + Lung + Footpad

40
Q

What is required for rt-PCR CDV test?

A

Presence of viral particle

41
Q

What can be used for a CDV rt-PCR?

A

Tissue - fresh or frozen

Whole blood + CSF + Urine

42
Q

What is the treatment for CDV?

A

Supprotive

Treat secondary bacterial ifnections

43
Q

What is seen upon necropsy in cattle with respiratory disease complex?

A

Severe Crainial ventral pneumonia

Affected tissue is firm

Minor fibrin deposits

44
Q

What are the four most common viruses in the respiratory disease complex?

A

BVDV

PI3

BRSV

IBR

45
Q

How do the majority of PI3 cases present?

A

Subclinical

46
Q

What is the pathogenesis of PI3?

A

Infection of ciliated epi cells + Alveolar cells + Macrophages

Loss of muciliary apparatus

Secondary bacterial infections

47
Q

What is the pathogensis of BRSV?

A

Replication in ciliated epi

Necrotizing bronchiolitis

Host response enhances pathology

Persistant infection

48
Q

What is seen upon histological examination of BRSV?

A

Syncytial formation in type 2 pneumocytes

49
Q

What is the method of prevention in PI3 + BRSV?

A

Address the environmental + stress concerns

Identify disease

Vaccines

50
Q

What is the homolog to BRDC in small animals?

A

Kennel cough

51
Q

What are the differientials for kennel cough?

A

Bordetella bronchiseptica

Mycoplasma

Canine adenovirus

Canine parainfluenza

52
Q

How is canine parainfluenza diagnosed?

A

Clincal history

53
Q

What is the treatment for canine parainfluenza?

A

Palliative

Symptomatic

54
Q

What is the respiratory disease in chickens?

A

Newcastle disease virus

55
Q

What symptoms are seen with new castle disease?

A

Acute respiratory disease

CNS signs

Diarrhea

56
Q

What are the three virulent groups of Newcastle?

A

Virulent

Moderately

Low

57
Q

Describe Moderately virulent newcastle

A

Mesogenic

58
Q

Describe virulent newcastle

A

Velogenic

59
Q

Describe low viruent Newcastle

A

Lentogenic

60
Q

What is seen upon necropsy of an animal with Newcastle?

A

Petichiae or hemorrhage +/- necrosis

Thymic edema

Respiratory congestion + mucoid exudates

Fungal/Virology (26 decks)

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