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Fungal/Virology > LEC 10 - Papilloma + Pox Virus > Flashcards

LEC 10 - Papilloma + Pox Virus Flashcards

1
Q

With ocular nasal discharge + skin lesions what would be important to sample from?

A

Lesions Lymph nodes Spleen

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2
Q

What tests should be ran with a animal that has ocularnasal discharge and skin lesions?

A

C/S

VI
EM

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3
Q

What are the differientials in an animals that has skin lesions + oculonasal discharge?

A

Tularemia

Plague

Herpes virus

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4
Q

What is the target when trying to make a conclusive diagnosis about which orthovirus an animal has?

A

Conserved/Degenerate PCR

Target: Hemagglutinin gene

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5
Q

What is the reservior for monkeypox?

A

Rodents

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6
Q

What diseases are under capripoxviruses?

A

Sheep/goat pox

Lumpy skin disease

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7
Q

What diseases are under leporioxivirus?

A

Rabbit Myxoma virus

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8
Q

Types of diseases: Orthopoxvirus

A

Vaccinia

Coxpox

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9
Q

Types of diseases: Parapoxviruses

A

ORF

Bovine papular stomatitis

Pseudocowpox

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10
Q

Types of diseases: Avipoxvirus

A

Fowlpox

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11
Q

What are the reportable poxvirus diseases?

A

Sheep/goat pox

Lumpy skin disease

Rabbit Myxoma virus

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12
Q

What is the structure of the pox virus?

A

Barrel/box structure

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13
Q

What is the genome in a pox virus made of?

A

dsDNA

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14
Q

Is poxvirus enveloped or not?

A

Yes

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15
Q

How does poxviruses get into the cell?

A

Fusion/Macropincytosis

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16
Q

Where does the pox virus replicate in the host cell?

A

Cytoplasm

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17
Q

What is the sequence of events in the poxvirus infection?

A

Fusion/macropinocytosis

Uncoating + early protein synthesis

Intermediate gene expression + DNA replication in cytoplasm

Late phase gene expression = structural proteins

Viral assembly

Virion

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18
Q

What types of virions do pox viruses make?

A

Intracellular mature virion

External enveloped virion

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19
Q

What does the intracellular mature pox virion do to the cell?

A

Lyse the cell no envelope

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20
Q

What are does the external enveloped virion do to the host cell?

A

Budding so does not harm the host cell immediately

May lyse later one

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21
Q

What is the incubation period for the pox virus?

A

3 to 5 days

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22
Q

What are the clinical signs of the pox virus?

A

Skin lesions - vesicles + scabbing

Lesions variably located

Mortality rare but can occur

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23
Q

How does immunity occur to the pox virus?

A

IFN - directed

Complement cascade

CTL-mediated

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24
Q

How does the pox virus evade the immune system?

A

Stealth + Mimicry

MHC I + CD4 down regulation + depletion

IFN + TNF receptor homologs

IL-10 homologs

Complement system disruption

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25
Q

What does poxvirus cause in bovine?

A

Bovine papular stomatitis

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26
Q

What is important to remember when working with a possible BVS case?

A

Zoonotic potential

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27
Q

What is the disease course of bovine papular stomatitis?

28
Q

What is the major clinical signs of bovine papular stomatitis?

A

Oronasal lesions

29
Q

What are the clinical signs of orf/contagious ecthyma?

A

Oronasal lesions

30
Q

How long does it take for contagious ecthyma to run its course/

31
Q

What is important to remember when working with Contagious ecthyma?

32
Q

What body systems are targeted with sheep/goatpox?

A

Dermal

Pulmonary

33
Q

What type of prevention is avalible for sheep/goatpox?

A

MLV

Subunit vaccines

34
Q

What is the mortality rate with sheep/goatpox?

A

Greater than 50$

35
Q

What is the target in lump skin disease?

A

Endothelium

36
Q

What is the problem with lumpy skin disease?

A

> 5% mortality

But great economic loss due to decrease in weight

37
Q

What type of prevention is used in lumpy skin disease?

A

MLV, subunit vaccines

38
Q

What animals are most affected by myxomatosis?

A

Oryctolagus rabbits (European)

Sylvilagus rabbits ( Cottontails + Jack rabbits) not killed by the virus

39
Q

What cells are targeted in Myxomatosis?

A

Lymphocytes

40
Q

What protection is avalible for myxomatosis?

A

MLV, non-lethal analog virus

41
Q

What is the mortality rate with myxomatosis?

42
Q

How are pox viruses transmitted?

A

Aerosol

Vector

Direct contact

Fomites

43
Q

What is the treatment for poxvirus infection?

A

Palliative

44
Q

What are the differientials for dermal neoplasias in a horse?

A

Equine sarcoid

Squamous cell carcinoma

Granulomas

Solar dermatitis

45
Q

What is seen upon histology of a dermal neoplasia that is due to equine sarcoids?

A

Spindle cells in interlacing bundles + whorls

Collagenous matrix

Low-moderarte mitotic rate

46
Q

What causes equine sarcoids?

A

Non-conforming bovine papillomavirus (BPV-2) infection

47
Q

What is the structure of the papilloma virus?

A

Icosahedral structure

48
Q

What is the structure of the genome in the papillomavirus?

49
Q

How does the papillomavirus enter the host cell?

A

Endocytosis

50
Q

Where does the papillomavirus replicate?

51
Q

What is the sequence of the papillomavirus replication?

A

Endocytosis

Transport to nucleus

Early protein transcription/translation

Late protein transcription/translation

+/- host chromosome integration

52
Q

What cell type is the papillomavirus endocytosed within?

A

Basal squamous epithelial cells

53
Q

What are the clinical signs of papillomavirus?

A

Proliferative lesions (warts) of the epithelium

Dermis, oral/gastric mucosas, bladder

54
Q

What is the major characteristic of the life cycle of a papillomavirus?

A

Lengthy + Variable incubation period

55
Q

How does the host immune system handle the papillomavirus?

A

Primarily cell mediated

Since doesn’t go in the blood rely on peripheral immune system

56
Q

How does the papilloma virus avoid the immune system?

A

Stealth - no viremia + non-cytolytic

IFN pathway inhibition

57
Q

What is the treatment for a papillomavirus infection?

A

Excision

Cryosurgery

Radiation + Chemotherapy

58
Q

What can happen in dogs with a papillomavirus infection?

A

Spontaneous regression

59
Q

What is the structure of the genome of african swine fever?

60
Q

What is the structure of the african swine fever virus?

A

Icosahedral, non-enveloped

61
Q

What is special about the african swine fever virus?

A

Only known DNA cirus with an arthropod vector (TICKS)

62
Q

How does african swine fever virus enter the host cell?

A

Viral endocytosis

63
Q

Where does the african swine fever virus replicate in the host cell?

64
Q

What is the sequence of events when it comes to the african swine fever virus?

A

Early gene trasncription + genome replication

Late gene trasncription (structural proteins)

Packaging + membrane budding

65
Q

What are the peracute signs of african swine fever?

A

Sudden death

66
Q

What are the acute signs of african swine fever?

A

Fever + ADR + Cutaneous hemorrhage

High mortality

67
Q

What are the subacute symptoms of african swine fever?

A

Pneumonia

Weight loss

Joint swelling

ADR

Variable mortality

Fungal/Virology (26 decks)

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