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Fungal/Virology > LEC 13 - Parvo + Circovirus > Flashcards

LEC 13 - Parvo + Circovirus Flashcards

1
Q

What is seen in a necropsy of an animal who died of parvo?

A

Petchial + diffuse hemorrhages

Pseudomembrane formation at intestinal mucosa

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2
Q

What type of testing can be done for the parvo virus?

A

Virus isolation

Hemagglutination inhibition

Parvrovirus ELISA

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3
Q

What is seen in a small intestine histopath in an animal infected with parvo virus?

A

Loss of crypt cells + villus atrophy with occasional eosinophilic IN inclusion bodies

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4
Q

What is the structure of the parvovirus?

A

Round + Icosahedral

Non-enveloped

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5
Q

What is the genome structure of the parvovirus?

A

ssDNA

Linear

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6
Q

What method is used by the parvovirus to gain entry into the host cell?

A

Viral endocytosis

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7
Q

Where does the parvovirus replicate in the host cell?

A

Nucleus

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8
Q

What is the sequence of events when it comes to replication of parvovirus?

A

Viral endocytosis

Permeabiliazation of endosomal membrane

Transport to nucleus

ssDNA > dsDNA

Host cell mitosis > viral mRNA transcription

Replication via rolling-hairpin mechanism

ssDNA encapsulation + Cell lysis

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9
Q

What are the original parvovirus?

A

Feline panleukopenia

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10
Q

What is important to know about CPV2a?

A

It is now able to infect both dogs + cats

Therefore need to keep these patients seperated from one another

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11
Q

What is the transmission process of parvovirus?

A

Feco-oral/aerosol transmission

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12
Q

Where in the body does the parvo virus replicate?

A

Local LN replication

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13
Q

How does the parvovirus travel in the body?

A

Disseminated viremia > target organs

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14
Q

What are the target organs for the parvovirus?

A

Bone marrow

Intestinal crypts

LN/Spleen

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15
Q

How long is there high-titer shedding in the feces for a parvo infection?

A

~3 days

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16
Q

Parvo virus - Clinical signs: Immature/Young adult

A

GI

Hematologic signs

17
Q

Parvo virus - Clinical signs: In utero

A

CNS - feline

Myocardium - K9

18
Q

Parvo virus - Clinical signs: Pregnant

A

Reproductive failure

19
Q

What are the overall clincial signs with a parvovirus infection?

A

Vomiting + Anorexia + Blood diarrhea

Anemia

Leukopenia -lymphopenia + thrombocytopenia

Hypoglycemia

Hypoproteinemia

20
Q

What are the clincial signs with Aleutian disease (parvovirus origin)?

A

Chronic, persistent, progressive

Immune complex disease (Glomerulonephritis + Arteritis)

PD

Diarrhea

Neuro signs

21
Q

What treatment is used in parvovirus infections?

A

Supportive

Fluids + Blood/plasma transfusion + Anti-emetics + Gastroprotectants

22
Q

What vaccines are available for parvo virus?

A

MLV (give at 8wk, 12 wk, + 12m)

Give inactivated to pregnant animals

23
Q

What are the clinical signs of porcine parvovirus?

A

SMEDI

Stillbirths

Mummification

Embryonic deaths

Infertility

24
Q

When do you see clinical signs with procine parvovirus?

A

10 to 14 days post exposure

1st half of gestation

25
Q

What is done to prevent porcine parvovirus infections?

A

Expose susceptible breeding animlas to older, exposed animals

Vaccinate 2-4 weeks prior to breeding

26
Q

What is the structure of circoviruses?

A

Round, isoahedral

Non-enveloped

27
Q

What is the genome structure of circoviruses?

A

Non-enveloped

28
Q

Where does circovirus replicate in the host cell?

A

Nucleus

29
Q

What is the sequence of events in replication of a circovirus?

A

Cell penetration

Viral uncoating

ssDNA to the nucleus

ssDNA > dsDNA

Viral mRNA transcription/translation

Rolling circle replication

Cell lysis + Viron release

30
Q

What is the transmission method of circoviruses?

A

Fecal-oral

31
Q

What does PCV-2 target in the body?

A

Rapidly diving cells

Immune stimulation

32
Q

What is the target of chicken anemia virus?

A

Early thymic T-cell target

33
Q

What is the target of psittacine beak + feather disease?

A

Lymphocytic

Feather follicles + beak/claw growth matrices

Fungal/Virology (26 decks)

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