Last part

Question 1

B cells provides signal … for the activation of lyphocytes

Answer 1

1

Question 2

what signals do innate molecules respond to?

Answer 2

2

Question 3

What do IFN a/b trigger?

Answer 3

response to intracellular TLF signaling and other sensors of viral RNA

Question 4

What does IFN a/b activate?

Answer 4

JAK STAT on neighboring uninfected cell, this produces expression of genes whose products interfere with viral replication

Question 5

What is a plasma protine that microbial strucutes and particifpates in innate immunity?

Answer 5

pentraxin family

Question 6

What are in the petraxin family?

Answer 6

c reactive protins CRP and serum amyloid P SAP

Question 7

WHat is the results of IL6 and IL1 in the liver?

Answer 7

increased amounts of CRP and SAP

Question 8

What does CRP and SAP do?

Answer 8

recognize phosphorylcholine and phosphatidylethanolamine, which are found on bacteria and apoptotic cells

Question 9

What can CRP and SAM activate?

Answer 9

complement by bdinging C1q and intiating the classical pathway

Question 10

complement pathways results in

Answer 10

complement proteins into protease complexes

Question 11

What cleaves the centra protine of the complement system?

Answer 11

C3 convertase

Question 12

C3 convertse cleaves C3 and makes

Answer 12

C3a and C3b

Question 13

What does the C3b fragment become?

Answer 13

covalently attached to the microbial surface

Question 14

What serves as an opsonin to promoe phagocytosis of the microbes?

Answer 14

C3b

Question 15

What does the C3b fragment do?

Answer 15

stimulates inflammation by acting as a chemoattractant for neutrophils

Question 16

C3b also cleaves to?

Answer 16

C5 convertase that cleaves C5,

Question 17

What does C5 cleaved generated?

Answer 17

a releasted peptide C5a dn a larger fragment C5b that remains attached to the microbial cell membrane

Question 18

WHat is a very potent chemoattractant that slo induces changes in the permeability of blood vessels?

Answer 18

C5a

Question 19

What complex does C5b initiate?

Answer 19

C6,7, 8, 9

Question 20

What is the complex called

Answer 20

mac

Question 21

How does classical pathway work?

Answer 21

uses plams protein called C1q to detect Abs bound to the surface of a microbe or other sturucture

Question 22

What does C1q do?

Answer 22

binds to the Fc portion of the antibodies, tw associated with serin proteases C1r and C1s become active

Question 23

What initiates a proteolytic cascade invloing other complement protins C2 and C4 in the classical pathway?

Answer 23

C1r and C1s

Question 24

C1s adds to C4 to make C4b

Answer 24

C1s adds to C2 to make C2a

Question 25

C4b and C2a bind and make

Answer 25

c3 convertase of the classical pathway

Question 26

What triggers the leptin pathway?

Answer 26

mannose-binding lectin