Lab 7 Flashcards

1
Q

Identify this structure:

A

granuloma

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2
Q

Identify this structure:

A

fibrous ring

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3
Q

Identify this structure:

A

macrophages

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4
Q

Why do fungal agents cause a granulomatous reaction?

A

fungi have complex call walls that are not easily killed by the killing mechanisms of neutrophils and tend to persist and require macrophages to kill them

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5
Q

What is the histomorphologic diagnosis of this lesion?

A

severe chronic widely disseminated pyogranulomatous pneumonia

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6
Q

Identify this structure:

A

multinucleated giant cells

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7
Q

Identify this structure:

A

heterophils

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8
Q

What type of inflammation is present in this skin mass from the turtle?

A

heterophilic and granulomatous inflammation

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9
Q

What is this dark staining?

A

surgical margins

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10
Q

This is a skin mass from a Lab. What cell type are present in this lesion?

A

macrophages, neutrophils centrally, lymphocytes and plasma cells peripherally

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11
Q

Identify this structure:

A

acid-fast bacteria

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12
Q

Identify this structure:

A

neutrophils

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13
Q

This is from a skin mass of a golden.What is the morphological diagnosis for this lesion?

A

granlomatous or pyogranulomatous dermatitis, focal, chronic, with intramacrophagic acid-fast bacteria

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14
Q

Identify this structure:

A

plasma cell

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15
Q

Identify this structure:

A

macrophages

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16
Q

Identify this structure:

A

neutrophils

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17
Q

Given the population of inflammatory cells here, what type of inflammatory exudate is this?

A

pyogranulonatous, or purulent and histiocytic

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18
Q

Provide a morphologic diagnosis for this lesion:

A

chronic, diffuse, severe, granulomatous ileitis

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19
Q

Histologically, what cells are seen in granulomatous inflammation?

A

predominately macrophages and fewer epitheliod macrophages and multinucleated cells

20
Q

What is a diffuse granuloma also known as?

A

lepromatous

21
Q

Grossly, what do nodular granulomas look like?

A

gray to white, round to oval, firm to hard, and well demarcated

22
Q

Grossly, what do tuberculoid granulomas look like?

A

well delineated, confined distribution, commonly have a fibrous component

23
Q

An acid-fast stain was performed on this slide from the intestine of a cow, what sort of pathogen is seen taking up stain in the slide?

A

acid-fast bacteria specifically M. avium in this lesion

24
Q

What is this?

A

a fibrous tag

25
Q

What are these raised edges?

A

nodules

26
Q

What is the yellow-ish material?

A

caseous necrosis

27
Q

Provide a morphologic diagnosis for this lesion:

A

chronic, severe, bilateral cranioventral bronchopneumonia with multifocal abcesses, caseating granulomas, and extensive fibrous adhesions

28
Q

What about this lesion indicates that it is chronic?

A

fibrous tags, fibrous connective tissue, caseous necrosis (chronic lesion with macrophages and neutrophils)

29
Q

What is the difference between fibrous tags and fibrin?

A

fibrin is white to tan, stringy material that is easily peeled off fibrous tags are tough, not easily broken down, and are adherent

30
Q

What are fibrous tags made of?

A

fibroblasts and collagen fibers

31
Q

What type of granulomatous inflammation is seen in this lesion?

A

nodular or tuberculoid type granulomatous inflammation

32
Q

What type of material is this?

A

friable caseous exudate

33
Q

Provide a morphologic diagnosis for this lesion:

A

chronic, multifocal, pyogranulomatous, caseous lymphadenitis

34
Q

What bacterial organism could cause this lesion in a sheep?

A

corynebacterium pseudotuberculosis

35
Q

List the events that need occur in order for a lesion to become chronic:

A

presence of an injurous substance persisting in the tissues, sustained tissue injury, parenchymal cell death with stromal and basement membrane damage, cellular infiltrates change from neutrophils to macrophages or lymphocytes, variable degrees of fibrosis are present

36
Q

Provide a morphologic diagnosis for this lesion:

A

chronic, focal, proliferative, severe laminitis

37
Q

Is this a chronic or an acute lesion?

A

chronic

38
Q

What mechanism causes the lamellar wedge in this lesion?

A

irregular hyperplasia of the epidermal lamellae

39
Q

Provide a morphologic diagnosis for this lesion:

A

chronic, focal, severe exuberant granulation tissue

40
Q

What is granulation tissue?

A

a fibrovascular tissue that is produced by the body to fill in spaces or defects

41
Q

How long does it take for granulation tissue to form?

A

1-2 weeks

42
Q

Provide a morphologic diagnosis for this lesion:

A

chronic, diffuse, severe, epicarditis and pericarditis

43
Q

At the time of necropsy, there was purulent fluid contained within the pericardial space. What is the significance of the clinical finding of purulent fluid?

A

the presence of purulent fluid indicates that neutrophils are still being actibely recruited to the site, which means the inciting cause is likely ongoing

44
Q

How are the gross lesions connected to the ventral pitting edema?

A

. Ventral pitting edema is likely due to progressive right heart failure. Because the right ventricular muscle mass is smaller, the pressure from the pericardial fluid affects the right side of the heart before the left. Decreased output causes expansion of the venous capacitance vessels-increased hydrostatic pressure.

45
Q

What are these?

A

multifocal tan, firm nodules

46
Q

Provide a morphologic diagnosis for this lesion:

A

chronic, multifocal, moderate hepatic abcesses

47
Q

What are the potential differentials for the nodules in the liver?

A

hyperplasia, abcess, neoplasia, granuloma