L2: DKA Flashcards
Metabolic Actions of Insulin
Metabolic Actions of Insulin
- CHO
Metabolic Actions of Insulin
- PTN
Metabolic Actions of Insulin
- Lipids
Metabolic Actions of Insulin
- Electrolytes
Def of DKA
Acute metabolic derangement in IDDM characterized by:
- Hyperglycemia
- Acidosis
- Ketosis
Etiology of DKA
- Insulin deficiency (absolute or relative)
- Elevation of counter regulatory hormones
- Concomitant reduction of insulinโs effective action
Etiology of DKA
- Insulin Deficiency
Etiology of DKA
- Elevation of counter regulatory hormones
Etiology of DKA
- Concomitant reduction of insulinโs effective action
- This overwhelms homeostatic mechanisms and lead to metabolic decompensation despite the patient taking the usual recommended dose of insulin
End Result leading to DKA
Pathophysiology of DKA
- Osmotic diuresis and hypovolemia
- Metabolic acidosis with increased anion gap
- Hypokalemia
Pathophysiology of DKA
- Osmotic Diuresis & Hypovolemia
Pathophysiology of DKA
- Metabolic Acidosis with Increased Anion Gap
Pathophysiology of DKA
- Hypokalemia
CP of DKA
Causes of increased or normal BP in DKA
- Increased plasma catecholamine concentrations
- Release of ADH in response to hyperosmolality
- Osmotic pressure from marked hyperglycemia
Dx of DKA
Dx of DKA
- Diabetic
Dx of DKA
- Keto
Dx of DKA
- Acidosis
Dx of DKA
- Relation Between hyperglycemia & Acidosis
The degree of hyperglycemia does not correlate with degree of acidosis
Severity of DKA
Calculation of Severity of DKA
- Anion Gap
- Corrected Na
- Effective Osmolarity
Calculation of Severity of DKA
- Anion Gap
Calculation of Severity of DKA
- Corrected Na
Calculation of Severity of DKA
- Effective Osmolarity
Problems of DKA
- Dehydration: moderate to severe
- Hyperglycemia
- Acidosis
- Electrolyte disturbance
- Precipitating factors
Managment of DKA
- Confirmation of diagnosis
- Emergency assessment & management
- Rehydration
- Insulin therapy
- K replacement
- Treatment of acidosis
- Treatment of precipitating factors
Managment of DKA
- Confirmation of DKA
Confirmation of DKA
- Blood Sample
Emergency Assessment of DKA
- Blood Glucose
- BOHB & Urine AAA
- Weight
- DHD
- Consciousness
Emergency Assessment of DKA
- BOHB & AAA
- blood BOHB
- urine test strips for acetoacetic acid
Emergency Assessment of DKA
- Glucose
Immediately measure blood glucose
Emergency Assessment of DKA
- Weight
The current weight should be used for calculations
Emergency Assessment of DKA
- DHD
Emergency Assessment of DKA
- Consciousness
Assess level of consciousness (Glasgow coma scale)
Indications of immediate treatment of DKA in ICU
Emergency Managment of DKA
Emergency Managment of DKA
- Airway
Emergency Managment of DKA
- Breathing
Emergency Managment of DKA
- Circulation
Emergency Managment of DKA
- Drugs & Maneuvers
Rehydration in DKA
- Objectives
- Restore circulating volume
- Replace sodium and the extracellular and intracellular water deficits
- Improve glomerular filtration and enhance clearance of glucose and ketones from the blood
Rehydration in DKA
- Deficit amount of DKA
- Moderate DKA: >5-7% Dehydration
- Severe DKA: 7 - 10% Dehydration
Rehydration in DKA
- Not in shock with good tissue perfusion
- Volume expansion (resuscitation) should begin immediately with 0.9% saline.
- 10 mL/kg infused over 30 - 60 minutes
Rehydration in DKA
- Not in shock with poor tissue perfussion
- The initial fluid bolus is given more rapidly (e.g., over 15 - 30 minutes)
- A second fluid bolus may be needed to ensure adequate tissue perfusion.
Rehydration in DKA
- In shock
- Rapidly restore circulatory volume with isotonic saline in 20 mL/kg boluses
- Infuse as quickly as possible
- Reassess circulatory status after each bolus.
Rehydration in DKA
- General Fluid Replacement
Replace the estimated fluid deficit at an even rate over 24 - 48 hr
Another method for calculation of deficit amount in DKA
Example of volumes of maintenance + 10% deficit, to be given evenly over 48h
Rehydration in DKA
- Types of Fluids
- IV Fluids
- Oral Fluids
Rehydration in DKA
- IV Fluids
- Saline
- Na
- Glucose
- K
IV Fluids Rehydration in DKA
- Deficit Replacement (Saline)
with a solution that has a tonicity 0.45% to 0.9% saline, with added KCI, potassium phosphate or potassium acetate
IV Fluids Rehydration in DKA
- Sodium
- should rise by 0.5 mmol/L for each 1 mmol/L t in glucose concentration
- The Na content of the fluid should be 1 if measured serum Na concentration is low & doesnโt rise appropriately as the plasma glucose concentration falls
IV Fluids Rehydration in DKA
- Glucose
IV Fluids Rehydration in DKA
- K
20 meq/L fluid taken
Oral Rehydration in DKA
- Severe DHD
- Mild DKA
Oral Rehydration in DKA
- In severe DHD & Acidosis
only sips of cold water
Oral Rehydration in DKA
- In mild cases of DKA & no vomiting
ORS with the usual volume calculation and subtracted from IV fluids
- Oral fluids as rehydration solution or juice only used after clinical improvement and no vomiting and subtracted from IV fluids (within 24hs of starting therapy)
โฆ
Can be used with the usual volume calculation and subtracted from IV fluids
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Insulin Therapy in DKA
- Time
- At least 1 hour after starting fluid replacement therapy and reversal of shock
Insulin Therapy in DKA
- Dose
Insulin Therapy in DKA
- Route
IV Route
Insulin Therapy in DKA
- Recommended Rate of Blood glucose drop
Insulin Therapy in DKA
- SC Insulin
K Replacment in DKA
- if hypokalemia
- Start K replacement at the time of initial volume expansion and before starting insulin therapy (Insulin causes an intracellular shift of K, which can cause life-threatening hypokalemia)
K Replacment in DKA
- if normokalemia
- Start replacing K after initial volume expansion and
concurrent with starting insulin therapy.
K Replacment in DKA
- If Hyperkalemic
Delay K replacement therapy until urine output is documented.
K Replacment in DKA
- Dose & Duration
- Starting K* concentration in the infusate should be 40 mmol/L then according to serum K*.
- With initial rapid volume expansion, a concentration of 20 mmol/L should be used.
- K* replacement should continue throughout IV fluid therapy.
- The maximum recommended rate of IV K* replacement is usually 0.5 mmol/kg/h.
K Replacment in DKA
- if hypokalemia persists
If hypokalemia persists despite a maximum rate of potassium replacement, the rate of insulin infusion can be reduced.
Profound hypokalemia (<2.5 mmol/L) in untreated DKA is rare and necessitates: โฆ..
TTT of Acidosis in DKA
TTT of Acidosis in DKA
- NaHCO3
TTT of Acidosis in DKA
- Dose
Cautiously give 1 - 2 mmol/kg over 60 minutes
TTT of Predisposing factors in DKA
e.g. treatment of sepsis
Prevention of DKA
CP (Warning Signs) of Cerebral Edema
Common errors in diagnosis & management of DKA
CP of Cerebral Edema
- Cushing Reflex
TTT of Cerebral Edema