L11: Neonatal Anemia Flashcards
Hb Level in Newborn
- 16 - 18 gm/dI
Due to stimulation of B.M. by relative intra-uterine hypoxia
Hb Level in old infants & Children
- 10 - 12 gm/dl
But this level represent anemia at birth
Physiological Anemia in Infancy
Physiological Anemia in Infancy
- In Utero
Physiological Anemia in Infancy
- After Birth
Anemia of Prematurity
Anemia of Prematurity
- Early
Hb nadir is lower (8-10 g/dl) & is reached earlier than term infant (5 - 10 weeks).
Anemia of Prematurity
- Late
- Iron administration before the age of 2 months โฆโฆ.
- However, this iron is stored for later use to prevent late anemia
doesnโt prevent early anemia of newborn
Causes of Anemia of Newborn
Causes of Anemia of Newborn
- Blood Loss
Causes of Anemia of Newborn
- Obsteric Blood Loss
- Abruption placenta & placenta previa.
- Incision of placenta inรญ C.S
- Rupture of the cord
Causes of Anemia of Newborn
- Occult Blood Loss
Causes of Anemia of Newborn
- Bleeding in Neonatal Period
Causes of Anemia of Newborn
- Hemolysis
Causes of Anemia of Newborn
- Immune Hemolysis
- Rh, ABO, or minor group incompatibility.
- Drug-induced hemolytic anemia (e.g., penicillin).
Causes of Anemia of Newborn
- Non-Immune Hemolysis
- Congenital or acquired infection.
- Vitamin E deficiency.
- RBC membrane disorders (e.g., hereditary spherocytosis).
- RBC enzyme deficiencies (e.g., G6PD deficiency)
- Acquired (e.g., DIC).
Causes of Anemia of Newborn
- Decreased RBCs Production
INVx for Anemia of Newborn
INVx for Anemia of Newborn
- Initial Labs
- CBC with RBC indices
- Peripheral blood smear
- Reticulocytic count
- Serum bilirubin
INVx for Anemia of Newborn
- Specific Tests
TTT of Anemia of Newborn
TTT of Anemia of Newborn
- Blood transfusion or packed RBCs
10-20 ml/kg
TTT of Anemia of Newborn
- Erythrocyte transfusion
Erythrocyte transfusion
- In cases with respiratory distress:
- Hematocrit < 35-40%
and/or
- Clinical evidence of hypovolemia (pallor, tachypnea, hypotension, poor perfusion)
Erythrocyte transfusion
- In cases without respiratory distress:
- Hematocrit < 25-30%
Iron Therapy