L17 - Atopy, Allergy & DHT 1 Flashcards
early phase reaction
what is this
timeframe
what is at a result of> cellulary
early phase reaction
basic mechanism
what happens what invoved – cells and other
early phase reaction
mediatiors, what is released from this
what is the pharmacological effects of the stuff released in this
pto for hints
GI tract airways bv's skin nose eyes lung
EG of allergen sources
what do these tend to be
general charactericts!!!! of them. why is this aid function
list of things pto
proteins
phyisical properties
moderate homolgy with self prot
anaphylaxs
what isthis
what caused by
effects to doff body parts? (PTO for list)
what are commonest triggers
CARDINAL FEATURES?!?!?!
cutaneous
gut
mucosal
circulation
clinical allergy syndromes
what are there x2
for oral
what is this
what happens
for airway
what different manifestations
what may allergens may be — types?!
ige directed against pollen protiens cross reacts iwth homologous protiens in plant derived foods
airway disease
rhinitis, longer airway obstruction
seasonal and episodic
immunological tightrope – what isit
origins of allergic disease??
allergic r atopic march
progression of disease observed from infancy
most outgrow eczema and many food allergies
can present de novo in adults
chronic allergic inflammation – asthma
what causes thus
what would biopsy show
what can explain this
–
late phase reaction
what happens here, what is present
what are the t cell subsets – what does a naive CD4 cell differentiate into
list of stuff prod on back, link to each t cell type
--- IL 9 IL 5 iFN -g IL 13 contact dep mechanism IL 17 IL 10 IL4
t cell subsets what does each produce: Th17 Treg Th1 Th2
pto for what some products do q
–
what do IL9 IL5 Il4 IL4 and 13 doooooo
Th2 hypothesis
why does this exist, whyyyy
what has been prev shown in biopsies
why would Th2 reponses be important in allergy?? go through each one lol
chronic allergic disease and asthma
what is the acute response what what causes it and what happens
chronic — what happens here
chronic repsinse caused by cytokines (from th2) and eosinophil products
LEAP study what is thus
hypegine hypothsis
—what is this
what do the factors invoved proposed to do
skew immunity from th2 to th1
induce treg cells
high hygeina nd all that does opposite
