L12 - Autoimmune Diseases 1

Question 1

define
autoimmunity
autoimmune disease
tolerance

Question 2

how are adaptive immune lymphocytes selected for?

why is the adaptive immune system prone to autoimmunity?

Question 3

what are various peripheral tolerance mechanisms

pto has list, explain how they work

Answer 3

immmunological hierarchy
antigen segregation
peripheral anergy
regulatory t cells
cytokine deviation
clonal exhaustion

Question 4

how to classify AID? give examples

Answer 4

–

Question 5

what type of hypersensitivity is AID?
what does this mean

what is the criteria for AID??

Question 6

what are different types of antibody mediated disease,
examples

pto list briefly explain

Answer 6

autoimmune haemolytic anaemia autoimmune thrombocytopaenia

autoimmune hyperthyroidism

myasthenia gravis

spontaneous urticaria

Question 7

antibody mediated disease - autoimmune cytopenias

how does this happen and what does it cause

Question 8

graves disease
what is it
what symptoms
how does it happen

Question 9

myasthenia gravis

what does it cause symptom wise
how does it happen pathophys

Question 10

spontaneous urticaria

what is it what happens

Question 11

how are antibodies related to autoimmune disease

Question 12

AID pathogenic mechanisms - t cells

what type of hypersensitivity
what do t cells do here

what types of T cell mediated autoimmune diseases are there

Question 13

autoimmune hypothyroidism

what mediates this
who?
what happes pathophys by what

Question 14

genetics and autoimmunity

what evidence shows importance??
what about environment?

also
what types of monogentic disorders and autoimmunity are there–I mean examples

Question 15

APACED

what is this - spell out
what type of disorder is it
what gene mutation causes this and what does that gene do
what happens as a result of the mutation
what is a key feature of the disease and why

what is APACED strongly associated with?

Answer 15

autoimmune polyglandular syndrome, candidasis and ectodermal dystrophy

Question 16

digeorge syndrome

why does this happen
what is the full phenotype of it
what genetic thing is causing
how does the syndrome generally present

Question 17

what syndrome presents with absent parathyroids, cleft palate, congenital heart defects and thymic aplasia.

what causes it

Question 18

IPEX
what type of disorder is it
spell out
what gene does this mutation effect
what happens as a result - physiology then clinically?

Answer 18

immune dysregulation, polyendocrinopathy, enteropathy, x-linked

Question 19

classical complement deficicencey

what type of disorder
what is deficient here and what does this predispose and why

what else does it predispose

Question 20

HLA system

what is it
what does it encode and where – also diff tyoes??
how does the nomemclature work
EG —- HLAb27

what is the expression of HLA molecules associated with

Question 21

coeliac disease
what? who affected?
what is it triggered by
what are the manifestations / effects

what are the pathology thingies
what do most individuals affected express????

Question 22

HLA and Coeliac

what is dietary gliadin degraded by, and WHEN

what does this produce

what happens next to the prodicts?? imuuuuune

Question 23

Coeliac pathogenesis

what is the damahe mediated by

how do resolve the inflammation

epidemioliogy of who expresses the thingies fo this?