L12 - Autoimmune Diseases 1 Flashcards
define
autoimmunity
autoimmune disease
tolerance
how are adaptive immune lymphocytes selected for?
why is the adaptive immune system prone to autoimmunity?
what are various peripheral tolerance mechanisms
pto has list, explain how they work
immmunological hierarchy antigen segregation peripheral anergy regulatory t cells cytokine deviation clonal exhaustion
how to classify AID? give examples
–
what type of hypersensitivity is AID?
what does this mean
what is the criteria for AID??
what are different types of antibody mediated disease,
examples
pto list briefly explain
autoimmune haemolytic anaemia autoimmune thrombocytopaenia
autoimmune hyperthyroidism
myasthenia gravis
spontaneous urticaria
antibody mediated disease - autoimmune cytopenias
how does this happen and what does it cause
graves disease
what is it
what symptoms
how does it happen
myasthenia gravis
what does it cause symptom wise
how does it happen pathophys
spontaneous urticaria
what is it what happens
how are antibodies related to autoimmune disease
AID pathogenic mechanisms - t cells
what type of hypersensitivity
what do t cells do here
what types of T cell mediated autoimmune diseases are there
autoimmune hypothyroidism
what mediates this
who?
what happes pathophys by what
genetics and autoimmunity
what evidence shows importance??
what about environment?
also
what types of monogentic disorders and autoimmunity are there–I mean examples
APACED
what is this - spell out
what type of disorder is it
what gene mutation causes this and what does that gene do
what happens as a result of the mutation
what is a key feature of the disease and why
what is APACED strongly associated with?
autoimmune polyglandular syndrome, candidasis and ectodermal dystrophy
digeorge syndrome
why does this happen
what is the full phenotype of it
what genetic thing is causing
how does the syndrome generally present
what syndrome presents with absent parathyroids, cleft palate, congenital heart defects and thymic aplasia.
what causes it
IPEX what type of disorder is it spell out what gene does this mutation effect what happens as a result - physiology then clinically?
immune dysregulation, polyendocrinopathy, enteropathy, x-linked
classical complement deficicencey
what type of disorder
what is deficient here and what does this predispose and why
what else does it predispose
HLA system
what is it
what does it encode and where – also diff tyoes??
how does the nomemclature work
EG —- HLAb27
what is the expression of HLA molecules associated with
coeliac disease
what? who affected?
what is it triggered by
what are the manifestations / effects
what are the pathology thingies
what do most individuals affected express????
HLA and Coeliac
what is dietary gliadin degraded by, and WHEN
what does this produce
what happens next to the prodicts?? imuuuuune
Coeliac pathogenesis
what is the damahe mediated by
how do resolve the inflammation
epidemioliogy of who expresses the thingies fo this?
