L04 - Adaptive Immunity 1 Flashcards
how do the features of the adaptive response compare to the innate?
slower,
recognition - initially low affinity receptors
gene rearrangement clonal expansion
t an b cells are encoded by fully rearranged genes
memory
compare the development of b and t cells
where?
how are they produced?
what are the recpetors like?
what is their development guided by?
what are the phases of development of b and t cells?
what hppens in each and where do they happen
B cell antigens
what types are there and why
what type of molecule are they
what type of signalling do they require
what are some of the responses of the t cell independant response
how do T independant antigens activate B cells by direct BCR aggregation
t-cell / b-cell collaboration
what is it required for?
what must happen for it to occur
what signals are needed and how do they occur?
t-cell dependent b-cell response
sequence of events?
–include receptor names and signals
mhc
th
cd80/cd86 to cd28
cd40 and cd40
antigen recognition by b-cells and t-cells
how do they form their antigen receptors
WHAT DO THEY CONSIST OF and what form are they in
how do they signal?
what can b cells and t cells bind to?
bcr - 2hc and 2;c
tcr - alphabeta heterodimer
