L08 - Cytokines and Chemokines Flashcards
how do all cytokines work?
what cytokines are important in haemapoesis
what are the various main types of mediators of host defence??
what do anti viral mediators do
give some examples and what are they made by
what do immune activators do
give examples and the things that activate them
what are cytotoxins
what are they produced by
give ecamples of them
what is IFN alpha and what is it produced by
IFN beta
IFN gamma
what does: IL-1 IL-2 /7/9/15 IFN gamma DOOOO
what does TNF do
what kind of molecules do these produce
CD8 cells
TH1 cells
TH2 cells
try and give egs of some of them
what cytokines fo TH1 cells produce and what are the effect of them
ifn gamma - macrophage destroy bacteria
fas ligand - kills chronically infected cells
IL2 - t cell prolif induced
IL3 and GMSF - macrophage diff in bone marrow induced
TNF alpha activated endothelium to induce macrophage binding and leave BV at infection site
how could immune stimulating cytokine deficiency cause immunosuppression?
what is an example of a particular condition be caused by
X linked SCID
X linked SCID - what is it and what happens and what does it effect
indlammatory cytokines
what are the cardinal signs and which cytokines (and others) can explain these
what happens when inflammation happens
what are some TNF mediated diseases
septic shock RA inflam bowel disease diabetes pul fibrosis multiple organ failure graft versus host rejection resp distress syndrome
——what kind of diseases are all these could be lumped in to
allergy and cytokines
which cell produces cytokines whcih are important here?
what are the major differences in the cytokines produced between the major cells
what are the subsets of T cells and what do they each produce and what do they do
IFN gamma
IL 17
IL-10
IL 4 /5 ./ 9 / 13
what are they all produced by and what do they do
TH`1
TH2
TH17
Treg
