L10 - Diseases of Immunology - Overview and classification

Question 1

how may the immune system fail to control infection?

how might the immune system cause disease directly?

give examples

Answer 1

–

Question 2

what is used to classify immunological mediated diseases

what types are there? what is each’s general overall mechanism and give examples if you can

Question 3

which type of immunological hypersensitivity is:

Pathological antibody directly causing diseases

Inflammation directly mediated by T cells

Antibody antigen complex mediated disease

IgE antibody directed against allergen triggers mast cell granulation

Question 4

type 1 hypersensitivity

what happens at a cellular level

Question 5

type 2 hypersensitivity in the AB blood system and transfusion

outline how all the blood groups and antigens work and donors

when do the associated antibodies (what are they) develop

what are the antibodies an example of and what does this mean

Question 6

define isoantibodies - what are they relavent to

where do they develop and what happens after this

Question 7

type 2 - haemolytic disease of the newborn

what is the secondary blood classification

what can go wrong in pregnancy in this

what causes the disease

what can happen to the foetus

Question 8

what is given to prevent haemolytic disease of the newbor and when does this happen – time and sitch

what happens with this on a cellular level

what is the risk reduced to

Question 9

what happens in autoimmune haemolysis?

classification?

Question 10

what does type 3 hypersensitivity describe

what happens in disease states and why

give examples

Question 11

what happens in local immune complex disease

(what type)

what is it indicitave of– what seen in

Question 12

what are painful lesions in the fingertip pulp could be?

Question 13

serum sickness

what type of hypersensitivity

what is it, why does it happen

examples

Question 14

hypersensitivity pneumonitis

aka?

what happens with this, what does a patient end up having happen to them as an effect

how do the symptoms occur and what causes this

what happens initially and over time

Question 15

what is it when

patient has repeated exposure to allergens and this causes them SOB and cough and lung scars shown on radiopgraphy?

Question 16

delayed type hypersensitiity

what type

what happens, how does this come about, what is it mediated by

what is it known as on the skin

Question 17

contact dermatitis

what is it
what happens at a cellular level, what cells do what

examples of what causes this?

Question 18

what are examples of type 4 hypersensitivity reactions

Question 19

TST - what is it

what is it used to determine

what happens with it -effect. what is it mediated by

Answer 19

–

Question 20

IGRA - interferon gamma release assay

what does it detect and how

what is done in thu=is test

positive and negative? and why

what method is used

what other method is there

Answer 20

elispot method

t-spot

ans elisa meythod

Question 21

how can you detect TB specific TH1 cells in vitro?

Question 22

what are the pros and cons of the gell and coombs classification