L15 - Tranplantation Immunology Flashcards
types of transplantation what are there
df of transplantation autografy isograft allograft xenograft
renal transplantation
what are the things that can go wrong
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what is the warm and cold ischaemic phase in transplantation
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what are the main types of graft refection
mechanisms?
time line?
antibodies and blood / serum
what Ab does serum contain
where are HLA antigens what are they
tests
what cells expres ABO antigens
which blood type can donate and recieve from what
how can HLA antibodies cause graft injuries
mechanism
what is activated produced led to prolif
what does it lead to
what can prevent hyperacute rejection
what is the most important part of the HLA molecule
what is cross matching?
how is it done
what is the mechanism behind hyperacute rejection and briefly outline
what is the mechanisms for acute rejection an dhow long
talk about TCR binding to self and non self cells
how does this occur and what is involved
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give some examples of drug therapy in immunosuppression
what do they do
once got answers, categorise each drug
cyclosporin A
tacrolimus
azathiopine
MMF
what drugs can be given to inhibit T cell? (how do they do this)
what can be given as an antiproliferative drug? how does this work
what increases immunogenicity and chronic rejection
what drugs can combat this. what do they do
what can block NFkB activation?
what else can this drug do
what is the gold standard for immunosuppression
what do they all do give eg
what is the mechanism for chronic rejection
why would you reduce immunosuppression after a few months
what is the balance you want to reach between
what are different views of transplantation? – philosophy and theory
what signals can activate APC’s? what are examples of these and what causes it
what different organs and tissues can be transplanted and what type of matching is needed
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