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204 [1] Immune System > L15 - Tranplantation Immunology > Flashcards

L15 - Tranplantation Immunology Flashcards

1
Q

types of transplantation what are there

A
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2
Q 
df of
transplantation
autografy
isograft
allograft
xenograft
A
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3
Q

renal transplantation

what are the things that can go wrong

A

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4
Q

what is the warm and cold ischaemic phase in transplantation

A

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5
Q

what are the main types of graft refection

mechanisms?

time line?

A
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6
Q

antibodies and blood / serum

what Ab does serum contain

where are HLA antigens what are they

tests

A
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7
Q

what cells expres ABO antigens

which blood type can donate and recieve from what

A
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8
Q

how can HLA antibodies cause graft injuries

mechanism
what is activated produced led to prolif
what does it lead to

A
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9
Q

what can prevent hyperacute rejection

what is the most important part of the HLA molecule

A
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10
Q

what is cross matching?

how is it done

A
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11
Q

what is the mechanism behind hyperacute rejection and briefly outline

A
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12
Q

what is the mechanisms for acute rejection an dhow long

A
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13
Q

talk about TCR binding to self and non self cells

how does this occur and what is involved

A

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14
Q

give some examples of drug therapy in immunosuppression

what do they do

once got answers, categorise each drug

A

cyclosporin A
tacrolimus
azathiopine
MMF

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15
Q

what drugs can be given to inhibit T cell? (how do they do this)

what can be given as an antiproliferative drug? how does this work

A
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16
Q

what increases immunogenicity and chronic rejection

what drugs can combat this. what do they do

A
17
Q

what can block NFkB activation?

what else can this drug do

A
18
Q

what is the gold standard for immunosuppression

what do they all do give eg

A
19
Q

what is the mechanism for chronic rejection

A
20
Q

why would you reduce immunosuppression after a few months

what is the balance you want to reach between

A
21
Q

what are different views of transplantation? – philosophy and theory

A
22
Q

what signals can activate APC’s? what are examples of these and what causes it

A
23
Q

what different organs and tissues can be transplanted and what type of matching is needed

A

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204 [1] Immune System (20 decks)

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