L12 - Autoimmune Diseases 2

Question 1

what is the explanantion for INFECTION leading to autoimmune diseases??? briefly outline

Question 2

molecular mimicry

what happens at infection? series of events. why does autoimmunity happen

what are examples of this? on back

Answer 2

what causes autoimmune haemolysis and rheumatic fever and how does it happen

Question 3

what does mycoplasma pneumonia cause and why

streptococcal infection

Question 4

T1 DM

how, what happen. onset. disease prev. trear? diff from others how

what is the evidence for autoimmune disease?!?!?!

progression of type one. what happens by the point of overt diabetes

Question 5

type 1 diabetes and genetics

how is it shown to be linked / important
what is the major defined risk factor???
—– why the risk factor happen, what it dioo
when would the autoimmune response occur

Answer 5

hla class II alleles

• ——- DR3 ORRR DR4 (rel risk is 6)
• ——- DR3 AND ——- RR15

Question 6

precipitating events for T1DM

why is identifying triggers difficult

what is there evidence for
—why (3)

Answer 6

—protein 2C from coxsackie virus has homology with islet cell antigen glutamic acid decarboxylase

Question 7

THE MULTISTEOP DEVELOPEMENT OF AID

whats involved, talk about each

Answer 7

mhc background
t cell repertoire
infection
plus other gen environ

Question 8

automimme serology for diagnosis

what can be used and why
what are the 3 methods for detection

Answer 8

indirect immunofluorescence
solid phase immunoassay
direct immunofluroescence

Question 9

indirect immunofluorescence

what does it detect and HOWWW- steps
what are the main ones

what can it be used for, but what ele could be used. for this disease, why is it important to identify, what are you look for

Question 10

immunoassay

how does it work

what is it being replaced by and why

Question 11

ELISA PRACTICAL

what is used
talk through the steps
!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

also what are the principles of the experiment, afterwards, and what is important to be done for the experiment. what is produced after

Question 12

ELISA PRACTICAL

what is used
talk through the steps
!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

also what are the principles of the experiment, afterwards, and what is important to be done for the experiment. what is produced after

Question 13

DIRECT immunofluorescence

what happens how is it different to indirect

Question 14

bulbous skin diseases
what are there and what are the features 
where are they
what is the antigen target
how does it happen

Question 15

pemphigus
pemphigoid

how do thy present
where is the target for antigens
what happens

Answer 15

pemphigus - intracellular cement protein desmolein 3 in superficial skin layers

pemphigoid
dermo-emidermal junction
activates complement producing skin dehiscence and tense bliser

Question 16

coeliac disease diagnosis

what does indirect immunofluresence
what antibodies have a strong assoc with this disease

what is the target antigen
what is it expressed in

what else can be looked for for diagnosis help

Question 17

pernicious anaemia

what happens here.
what happens as a result

how does the body initially cope but then what happens once it cant

Answer 17

–

Question 18

treating AID

what do you want to focus on and why – reasonS

examples of treatments?

what other kinds of treatment are helpful and for what

Question 19

what drugs are used for immunomodulation

what are they useful for
what is given
EGGGG

Answer 19

systemic corticosteroids
small molecule immunosuppressive srugs——-methotrexate, azathioprine, ciclosporin
high dose IV

Question 20

plasmapharesis

what is it and what is it useful in
what other autoimmune diseases are therw