L11 - Mucosal Immunology Flashcards
what is MALT, BALT, GALT
why is mucosal immunology important?
what are the main defences of the intestinal mucosa and oropharunc?
along the GI tract where is the most amount of lymphoid tissue found?
how does
enogenous flora
epitheliium and mucus
regionised immune system and gut homing
defend??
intestinal epithelial cells – what is there overall function (and not)
what do each of them do what what do they produce and how does this help
intetstinal epithelium cells
which
- –expresses TLRs and intracytoplasmic NLRs
- –produces mucus
- –produce HD5 and 6 precurser and trypsin
- –transport antigens to subepithelial lymphoid structures
- –
Peyer’s patches and associaed immune cells
what do they contain
where are they located
what are the numbers of patches like through life?
what are the 3 main domains
peyer’s patches
how does the follicle associated epithelium differ to normal epith?
what is the venous and lymphatic connections to them like? what to what
—-also what else can travel through
peyer’s patches
m-cells
what are their features — what are the advantages of some of them
peyer’s patches
why s it important that they have large cell memebrane fenestrations?
what do they exocyose?
Mesenteric lymph nodes
where are they what do they do? what are they the site for?
what happens if it is bypassed?
–
what is the main site for oral tolerance induction?
how does it work
–
lamina propria and intraepithelial lymphocyte compartment
where is the IEL??
what is its shape like
how can the cell be divided into different groups?
what are ligands assoc. what is TL,what do
IEL
main t cell subgroups?
what ligands are found on these cells, and where else could they be found
what happens when a virus infects a mucosal epithelium cell??? what is displayed, used to kill, what happens to the cells after
lamina propria and IEL comparetment
what are the mucosal T cells
what do each of them do
what do dendritic cells do?
which mucosal t cell from the lamina propria and IEL:::
produce IFN-gamma?
produce IL17 and IL22?
produce IL4 and IL-13?
produce IL-10?
what are these substances each important for?
mucosal b cells and IgA
how is IgA transported/ secreted? what is involved in this
what is the effect of sIgA, pIgA and pIgM? what is limitation of sIgA?
