L03 - Innate Immunity 2

Question 1

what do the cells of the innate immune system include?

what is NETs and what do they do

Question 2

how does phagocyte recruitment happen?

what cells perform phagocytosis? what things can help this

what antimicrobial mechanisms are there for phagocytosis?

Question 3

PRRs

what are they what do they do.what they are involved with? list different kinds

Answer 3

PRR recognise patterns called PAMPs

receptors include TLRs, NLRs, RLRs, CDs

Question 4

PAMPs
what are they and what do they focus on

and DAMPs
what are they when are they released by what

Question 5

drosophilia toll receptors

what did research find?? what are they important for

what is mammalian equivalent

Question 6

what is the structure of toll like receptors

how do they function as functional hetero/homodimers

Answer 6

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Question 7

what do TLRs recognise exogenously and endogenously?? which type of TLRs for each
—- cell surface vs endosomal.

what does TLR signalling lead to? what are the two pathways?

Question 8

what does a MyD88 gain of function mutation lead to?

what about if you had a lack of MyD88?

Question 9

what can it mean if you have a lack of TLRs? when else could this happen

TLRs in disease - list things for infection and inflammation and which TLRs are associated for each example.
—————–then the same but for TLR agonist and antagonists

Question 10

TLRs and disease. which TLRs are associated with:

INFECTION - HIV? Sepsis? TB?
INFLAMMATION - System lupus erythmatosus? alheimers? atherosclerosis?

TLR agonists - Genital warts? Cancer? Allergy?
TLR antagonists - Autoummunity? Sepsis?

Question 11

NOD like receptors

what are they. what are the major groups of them – full names?

Answer 11

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Question 12

NRLCs

what are they
what are two examples of them
what can they do and how?

Question 13

NOD1 and NOD2

what are they

what do each bind to. what types of bacteria do these effect

what can a GAIN and LOSS of NOD2 lead to

Question 14

NLRPs

what are they
what is an example of it - common
what is it actived by
what is it essential for

Question 15

what are inflammasomes?
what are they activated by?
what does its activation lead to?

Question 16

NLR3 gain of function mutations

what are the resulting conditions referred to?
what are two examples of the syndromes? what are they triggered by and SYMPTOMS

Answer 16

-CAPS - cyropyrin associated periodic syndromes

Question 17

RLRs
what are they (function).. what are two examples. what do they actually do

what does each one do

Question 18

cytosolic DNA sensors
what is an autoimmune disease associated with this? what is its full name and abbrev?
qhat is it caused by
what do patients present with?

Question 19

acute phase response

what is induced by? and when
where are the things produced mainly
what do they lead to
what can be used to clinically detect inflammation