L14 - Pharmacological aspects of Immunology Flashcards
brief history
what are NSAIDS? examples
eicosanoid pathway
outline. pathways n enzymes
NSAID mechanism
how do they all work
what are the isoforms and how do they difeer
NSAID mechanism
COX1,COX2. COX3
when are they present and where and what do they do. what happens when inhibited
what is NSAID therapy indicated for
different situationa and examples
mild / potent analgesia and anti inflam
aspirin
what is it used and not used for and WHY
examples of aspirins
paracetemol
features of it
whatd does it do and doesn’t do / have
effectiveness compared to other NSAID
paracetamol
METABOLISM
overview of network of what happens to it
pto for hints
what can be used in poisoning
phase 2 conjugation reaction for excretion
phase 1 oxidation reacton —> hepatic necrosis
phase 2 again
NSAID GI toxicity
why is this the case and what does it lead to
risk factor - rel risk and what are tehy
NSAID nephrotoxicity
why does this happen – as a consequence what arre teh effects
what happens as worst scnario
when would you therefore avoid giving this in
asthma and aspirin
what is the link here and possible reason why
list some NSAIDs and order thim in potency and side effects magnitidue
what to do if someone has NSAID toxicity or you dont want it to happen
what would you treat with
misoprostil is PGe1 analogue / pp inhib
selective COX-2 inhibitors
what effects do they have in humans
what other effects
examples of these drugs
coxibs - efficacy
how does it compare to other NSAIDs, also in terms of what examples
GI side effects?
what other risk things are relavent to talk about here?
when should such drugs be used according to BNF
corticosteroids
example - what is this and what DOES IT DOOOOo
how does it work immunolgically – what is invoved
immunomodulation effects by steroids
what are they!!
pto for hints
cell trafficking
cell function
what doesn’t it effect
steroids
clinical uses? examples for each
pto for hints
what are the routes of administration and what properties can differ
inflammation suppression
suppress specific immunity
replacement therapy
corticosteroids as drugs
which five drugs are there??
how do they differ in terms of potency, lipid solubility, systemic use, topical use
pto for names
hydrocortisone prednisolone beclomethasone dexamethasone triaminiclone
steroid therapy side effects
early and later effects list
adrenal suppression during corticosteroid therapy
what happens with this and what needs to be careful here. explain why and what may happen, what can be done
what is something that steriods increase the risk of infection
what is this risk related to
what are specific examples of this, and when do they occur
pto for hints
risk of infection
phagocytic defects
cell mediated defects
