Kidney Structure And Filtration Flashcards

1
Q

What are the main blood vessels to the kidneys

A

Renal artery and Renal vein

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2
Q

What takes fluid to the kidney

A

Ureter

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3
Q

What encases the cortex and medulla

A

Capsule

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4
Q

Where does most blood flow go

A

To the renal cortex

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5
Q

Explain how blood/fluid gets to the renal columns in between medulla and cortex

A

From renal pelvis to the calyx

Calyx feeds into columns

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6
Q

How does fluid from the collecting duct get to the renal pelvis for excretion

A

Via the calyx

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7
Q

What are the 2 types of nephrons

A

Cortical nephron (mostly in cortex)

Juxtamedullary nephron (both cortex and medulla)

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8
Q

Which vessel feeds into glomerular capillaries

A

Afferent arterioles

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9
Q

Which arteriole leaves the glomerular ball of capillaries and what does it branch off into

A

Efferent arteriole

Branches off to peritubular capillaries which wrap around nephron

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10
Q

What 3 ways do kidneys regulate ions and water

A

Regulation of osmolarity/ ions

Regulation of ecf

Regulation of ph

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11
Q

Name some hormones produced by kidney

A

Erythropoietin
Thrombopoietin
Kinins (vasodilators)
Renin

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12
Q

Which 2 things kidneys produce regulate BF

A

Prostaglandins and kinins

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13
Q

Which vitamin is produced by kidney

A

D

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14
Q

What do peritubular capillaries feed into

A

Renal vein back to heart

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15
Q

What 2 things restrict filtration

A

Size and charge

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16
Q

How much of blood is filtered into glomerulus

17
Q

What is the measure of how much blood filtered in a minute

A

Glomerular filtration rate

18
Q

What is the name for the bowmans capsule with the capillaries

A

Renal corpuscle

19
Q

What are the double membranes of bowmans capsule

A

Basement membrane

Then podocytes

20
Q

What are the gaps between podocytes called

A

Filtration sites

21
Q

What are the cells called in capillary wall

A

Fenestrated endothelial cells

22
Q

What kind of things enter nephron

A

Ions eg na cl k

Urea / waste

Water

Glucose

23
Q

Which pressure drives filtration

A

Hydrostatic pressure of blood in capillaries

24
Q

Which 2 pressures oppose filtration via HP of capillaries

A

Colloid osmotic pressure

Bowmans fluid osmotic pressure

25
What does colloid osmotic pressure cause
Retention back into capillaries
26
How do you work out net filtration pressure
HP in capillaries - colloid osmotic pressure- bowmans fluid HP
27
How does change in resistance/ diameter of afferent arteriole affect HP in capillaries
Vasoconstriction causes increased resistance decreasing filtration rate / HP Vasodilation causes increase in HP and thus filtration rate
28
How does resistance / change in diameter of efferent arteriole affect HP in capillaries
Vasoconstriction causes back flow into capillaries Increasing HP Increasing filtration rate Vasodilation of efferent decreases HP
29
Which 2 things stay constant despite change in BP
Filtration rate and blood flow
30
How does the myogenic auto regulation response cause constant GFR and BF
If there’s an increase in pressure it causes stretch in the muscles which causes vasoconstriction eventually This increases resistance which decreases HP in capillaries causing lower GFR
31
What is tubuloglomerular feedback
Where fluid flow in tubules affects arteriole resistance
32
Which types of cells in the DCT can affect the A and E arteriole walls diameter
Macula densa cells
33
What do macula densa cells release to affect GFR via resistance
Para crine factors
34
Explain the steps of what would happen in tubuloglomerular feedback
Increased GFR Increases flow in tubules past macula densa cells Sensed by cells via na/Cl conc They release me paracrine factors eg adenosine or atp Causes vasoconstriction Decreases GFR
35
Adenosine and atp are vasoconstrictors from macula densa cells, what is released for vasodilation
NO
36
How is flow in macula densa cells detected
Via na or Cl conc