ISBB Flashcards

1
Q

Cross immunity

A. Edward Jenner
B. Louis Pasteur

A

A. Edward Jenner

*Cowpox, small pox

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2
Q

Father of Immunology/ First attenuated vaccine

A. Edward Jenner
B. Louis Pasteur

A

B. Louis Pasteur

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3
Q

Discovey of T cell receptor gene

A. 1798
B. 1880
C. 1901
D. 1984

A

D. 1984

  • By Tak Wah Mak, Mark Davis
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4
Q

Serum antitoxin

A. Robert Koch
B. Emil von Behring

A

B. Emil von Behring

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5
Q

Cellular immunity in TB:

A. Robert Koch
B. Elie Metchnikoff
C. Charles Ricket
D. Jules Bordet
E. Karl Landsteiner
F. Paul Ehrlich

A

A. Robert Koch

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6
Q

Complement:

A. Robert Koch
B. Elie Metchnikoff
C. Charles Ricket
D. Jules Bordet
E. Karl Landsteiner
F. Paul Ehrlich

A

D. Jules Bordet

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7
Q

Anaphylaxis:

A. Robert Koch
B. Elie Metchnikoff
C. Charles Ricket
D. Jules Bordet
E. Karl Landsteiner
F. Paul Ehrlich

A

C. Charles Ricket

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8
Q

Human Blood Group antigens:

A. Robert Koch
B. Elie Metchnikoff
C. Charles Ricket
D. Jules Bordet
E. Karl Landsteiner
F. Paul Ehrlich

A

E. Karl Landsteiner

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9
Q

Immunity:

A. Robert Koch
B. Elie Metchnikoff
C. Charles Ricket
D. Jules Bordet
E. Karl Landsteiner
F. Paul Ehrlich

A

F. Paul Ehrlich

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10
Q

Phagocytosis:

A. Robert Koch
B. Elie Metchnikoff
C. Charles Ricket
D. Jules Bordet
E. Karl Landsteiner
F. Paul Ehrlich

A

B. Elie Metchnikoff

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11
Q

Structure of antibodies:

A. MacFarlane Burnet, Peter Medewar
B. Gerald Edelman, Rodney Porter
C. Rosalyn Yalow
D. George Snell, Jean Dausset, Baruj Benaceraf
E. Niels Jerne

A

B. Gerald Edelman, Rodney Porter

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12
Q

Discovery of Immunologic tolerance

A. MacFarlane Burnet, Peter Medewar
B. Gerald Edelman, Rodney Porter
C. Rosalyn Yalow
D. George Snell, Jean Dausset, Baruj Benaceraf
E. Niels Jerne

A

A. MacFarlane Burnet, Peter Medewar

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13
Q

Immunoregulation

A. MacFarlane Burnet, Peter Medewar
B. Gerald Edelman, Rodney Porter
C. Rosalyn Yalow
D. George Snell, Jean Dausset, Baruj Benaceraf
E. Niels Jerne

A

E. Niels Jerne

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14
Q

Radioimmunoassay

A. MacFarlane Burnet, Peter Medewar
B. Gerald Edelman, Rodney Porter
C. Rosalyn Yalow
D. George Snell, Jean Dausset, Baruj Benaceraf
E. Niels Jerne

A

C. Rosalyn Yalow

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15
Q

Major Histocompatibility complex

A. MacFarlane Burnet, Peter Medewar
B. Gerald Edelman, Rodney Porter
C. Rosalyn Yalow
D. George Snell, Jean Dausset, Baruj Benaceraf
E. Niels Jerne

A

D. George Snell, Jean Dausset, Baruj Benaceraf

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16
Q

Transplantation

A. Georges Koehler, Cesar Milstein
B. Susumu Tonegawa
C. Edward Donnall Thomas, Joseph Murray
D. Peter Doherty, Rolf Zinkernagel
E. Francois Barre-Sinoussi, Luc Montagnier

A

C. Edward Donnall Thomas, Joseph Murray

17
Q

Monoclonal antibody

A. Georges Koehler, Cesar Milstein
B. Susumu Tonegawa
C. Edward Donnall Thomas, Joseph Murray
D. Peter Doherty, Rolf Zinkernagel
E. Francois Barre-Sinoussi, Luc Montagnier

A

A. Georges Koehler, Cesar Milstein

18
Q

Antibody Diversity

A. Georges Koehler, Cesar Milstein
B. Susumu Tonegawa
C. Edward Donnall Thomas, Joseph Murray
D. Peter Doherty, Rolf Zinkernagel
E. Francois Barre-Sinoussi, Luc Montagnier

A

B. Susumu Tonegawa

19
Q

Human immunodeficiency virus

A. Georges Koehler, Cesar Milstein
B. Susumu Tonegawa
C. Edward Donnall Thomas, Joseph Murray
D. Peter Doherty, Rolf Zinkernagel
E. Francois Barre-Sinoussi, Luc Montagnier

A

E. Francois Barre-Sinoussi, Luc Montagnier

20
Q

Cytotoxic T cell recognition of virally infected cells

A. Georges Koehler, Cesar Milstein
B. Susumu Tonegawa
C. Edward Donnall Thomas, Joseph Murray
D. Peter Doherty, Rolf Zinkernagel
E. Francois Barre-Sinoussi, Luc Montagnier

A

D. Peter Doherty, Rolf Zinkernagel

21
Q

First Responder to INFECTION, PHAGOCYTOSIS

A. EOSINOPHILS
B. NEUTROPHILS
C. BASOPHILS
D. MAST CELLS

A

B. Neutrophils

22
Q

PHAGOCYTOSIS; kill INTRACELLULAR PARASITES, TUMORCIDAL activity; antigen presentation to T AND B CELLS

A. EOSINOPHILS
B. NEUTROPHILS
C. MONOCYTES
D. MAST CELLS

A

C. MONOCYTES

23
Q

KILL PARASITES, neutralize BASOPHILS and MAST CELL PRODUCTS, regulate Mast Cells

A. EOSINOPHILS
B. NEUTROPHILS
C. LYMPHOCYTES
D. MONOCYTES

A

A. EOSINOPHILS

24
Q

Antigen presenting to T and B cells; enhancement and suppression of the adaptive immune response

A. EOSINOPHILS
B. NEUTROPHILS
C. BASOPHILS
D. MAST CELLS

A

D. Mast Cells

25
Q

Induce and maintain ALLERGIC REACTIONS, stimulate production of IgE

A. DENDRITIC CELL
B. LYMPHOCYTES
C. BASOPHILS
D. MAST CELLS

A

C. Basophils

26
Q

MOST POTENT PHAGOCYTIC CELL, Most effective at antigen presentation

A. DENDRITIC CELL
B. LYMPHOCYTES
C. BASOPHILS
D. MAST CELLS

A

A. DENDRITIC CELL

27
Q

Subtypes are T cells, B cells and NK cells

A. DENDRITIC CELL
B. LYMPHOCYTES
C. BASOPHILS
D. MAST CELLS

A

B. LYMPHOCYTES

  • T Cells: Produces Cytokines
    B Cells: Produce antibody in Adaptive Immune Response
    NK Cells: Involved in innate immunity
28
Q

PRIMARY LYMPHOID ORGANS:

A. SPLEEN
B. LYMPH NODES
C. BM
D. MALT

A

C. BM

  • PRIMARY LYMPHOID ORGANS:
    BM
    THYMUS
29
Q

Produces hematopoietic stem cells; maturation of B cells and NK cells

A. BM
B. Thymus

A

A. BM

30
Q

Maturation of T Cells

A. BM
B. Thymus

A

B. Thymus

31
Q

•Developed in THYMUS
•60-80% Circulating pool in Blood
• ADAPTIVE IMMUNITY
• end product of activation are CYTOKINES
• ANTIGENS INCLUDE : CD2, CD3, CD4 CD8

A. B cells
B. T cells
C. NK cells

A

B. T Cells

32
Q

•Developed in BM
•10-15% or 20-35% Circulating in Lymphocyte pool in the Blood
•ADAPTIVE IMMUNITY
•end product of activation is ANTIBODY
•ANTIGENS INCLUDE CD19, CD20, CD21, SURFACE ANTIBODY

A. B cells
B. T cells
C. NK cells

A

A. B Cells

33
Q

•Developed in BM
•5-15% Circulating in Lymphocyte pool in the Blood
•INNATE IMMUNITY
•ANTIGENS INCLUDE CD16, CD56

A. B cells
B. T cells
C. NK cells

A

C. NK Cells

34
Q

Lacks CD4 & CD8

A. DOUBLE NEGATIVE THYMOCYTES
B. DOUBLE POSITIVE THYMOCYTES

A

A. DOUBLE NEGATIVE THYMOCYTES

35
Q

Express both CD4 CD8

A. DOUBLE NEGATIVE THYMOCYTES
B. DOUBLE POSITIVE THYMOCYTES

A

B. DOUBLE POSITIVE THYMOCYTES

36
Q

Either CD4 OR CD8, MIGRATE TO MEDULLA

A. MATURE T CELLS
B. ACTIVATED T CELLS
C. SENSITIZED T CELLS

A

A. MATURE T CELLS

37
Q

Activated T lymphocytes express receptors for IL-2

A. MATURE T CELLS
B. ACTIVATED T CELLS
C. SENSITIZED T CELLS

A

B. ACTIVATED T CELLS

38
Q

Differentiate into functionally active small lymphocytes that produces CYTOKINES

A. MATURE T CELLS
B. ACTIVATED T CELLS
C. SENSITIZED T CELLS

A

C. SENSITIZED T CELLS