IMMUNOSERO MUST KNOW

Question 1

Anaphylaxis

Answer 1

C3a, C4a, C5a

Question 2

Opsonization

Answer 2

C3b, inactive C3

Question 3

Neutrophil chemotaxis

Answer 3

C5a

Question 4

Cytolysis by membrane attack complex

Answer 4

C5b6,7,8,9

Question 5

Deficient C1 esterase inhibitor

Answer 5

hereditary angioneurotic edema

Question 6

Deficient C1 C2 C4

Answer 6

SLE-like and collagen vascular disorder

Question 7

Most common compliment deficiency

Answer 7

C2

Question 8

Severe recurrent infection, glomerulonephritis

Answer 8

C3

Question 9

Recurrent Neisseria infections

Answer 9

C5 C6 C7 C8

Question 10

No associated disease

Answer 10

C9

Question 11

Paroxysmal nocturnal hemoglobinuria

Answer 11

CD55/DAF; CD59/MIRL

Question 12

Atypical or non-epidemic hemolytic uremic syndrome

Answer 12

CD46/ FACTOR H/ FACTOR I

Question 13

Dissociates C1r and C1s from C1q

Answer 13

C1 inhibitor

Question 14

Proteolytically cleaves C3b And C4b

Answer 14

Factor I

Question 15

Cofactor of factor I to inactivate C3b
Prevents binding of B to C3b

Answer 15

Factor H

Question 16

Cofactor of factor I to inactivate C4b

Answer 16

C4-binding protein

Question 17

Increases the dissociation of C3 convertase:

Answer 17

DAF

Question 18

Membrane Inhibitor of Reactive (MIRL);
Inhibits Formation of MAC

Answer 18

CD59

Question 19

Prevents attachment of C5b67 to cell membrane

Answer 19

S protein (vitronectin)

Question 20

CLASSICAL PATHWAY:

Binds to Fc of IgM or IgG

Answer 20

C1q

Question 21

CLASSICAL PATHWAY:

Activate C1s

Answer 21

C1r

Question 22

CLASSICAL PATHWAY:

Cleaves C4 and C2

Answer 22

C1s

Question 23

CLASSICAL PATHWAY:
Key intermediate (all pathways)

Answer 23

C3

Question 24

CLASSICAL PATHWAY:

Initiates MAC

Answer 24

C5

Question 25

CLASSICAL PATHWAY:

Starts pore formation

Answer 25

C8

Question 26

CLASSICAL PATHWAY:

Polymerizes to cause cell lysis

Answer 26

C9

Question 27

ALTERNATIVE PATHWAY:

Binds C3b To Form C3 Convertase

Answer 27

Factor B

Question 28

ALTERNATIVE PATHWAY:

Cleaves Factor B

Answer 28

Factor D

Question 29

ALTERNATIVE PATHWAY:

Stabilizes C3 convertase

Answer 29

Factor P or Properdin

Question 30

LECTIN PATHWAY:

Binds to Mannose

Answer 30

MBL

Question 31

LECTIN PATHWAY:

Helps cleave C4 and C2

Answer 31

MASP-1

Question 32

Cleaves C4 and C2

Answer 32

MASP-2