IMMUNOSERO MUST KNOW Flashcards

1
Q

Anaphylaxis

A

C3a, C4a, C5a

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2
Q

Opsonization

A

C3b, inactive C3

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3
Q

Neutrophil chemotaxis

A

C5a

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4
Q

Cytolysis by membrane attack complex

A

C5b6,7,8,9

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5
Q

Deficient C1 esterase inhibitor

A

hereditary angioneurotic edema

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6
Q

Deficient C1 C2 C4

A

SLE-like and collagen vascular disorder

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7
Q

Most common compliment deficiency

A

C2

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8
Q

Severe recurrent infection, glomerulonephritis

A

C3

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9
Q

Recurrent Neisseria infections

A

C5 C6 C7 C8

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10
Q

No associated disease

A

C9

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11
Q

Paroxysmal nocturnal hemoglobinuria

A

CD55/DAF; CD59/MIRL

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12
Q

Atypical or non-epidemic hemolytic uremic syndrome

A

CD46/ FACTOR H/ FACTOR I

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13
Q

Dissociates C1r and C1s from C1q

A

C1 inhibitor

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14
Q

Proteolytically cleaves C3b And C4b

A

Factor I

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15
Q

Cofactor of factor I to inactivate C3b
Prevents binding of B to C3b

A

Factor H

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16
Q

Cofactor of factor I to inactivate C4b

A

C4-binding protein

17
Q

Increases the dissociation of C3 convertase:

18
Q

Membrane Inhibitor of Reactive (MIRL);
Inhibits Formation of MAC

19
Q

Prevents attachment of C5b67 to cell membrane

A

S protein (vitronectin)

20
Q

CLASSICAL PATHWAY:

Binds to Fc of IgM or IgG

21
Q

CLASSICAL PATHWAY:

Activate C1s

22
Q

CLASSICAL PATHWAY:

Cleaves C4 and C2

23
Q

CLASSICAL PATHWAY:
Key intermediate (all pathways)

24
Q

CLASSICAL PATHWAY:

Initiates MAC

25
CLASSICAL PATHWAY: Starts pore formation
C8
26
CLASSICAL PATHWAY: Polymerizes to cause cell lysis
C9
27
ALTERNATIVE PATHWAY: Binds C3b To Form C3 Convertase
Factor B
28
ALTERNATIVE PATHWAY: Cleaves Factor B
Factor D
29
ALTERNATIVE PATHWAY: Stabilizes C3 convertase
Factor P or Properdin
30
LECTIN PATHWAY: Binds to Mannose
MBL
31
LECTIN PATHWAY: Helps cleave C4 and C2
MASP-1
32
Cleaves C4 and C2
MASP-2