IMMUNOSERO MUST KNOW Flashcards
Anaphylaxis
C3a, C4a, C5a
Opsonization
C3b, inactive C3
Neutrophil chemotaxis
C5a
Cytolysis by membrane attack complex
C5b6,7,8,9
Deficient C1 esterase inhibitor
hereditary angioneurotic edema
Deficient C1 C2 C4
SLE-like and collagen vascular disorder
Most common compliment deficiency
C2
Severe recurrent infection, glomerulonephritis
C3
Recurrent Neisseria infections
C5 C6 C7 C8
No associated disease
C9
Paroxysmal nocturnal hemoglobinuria
CD55/DAF; CD59/MIRL
Atypical or non-epidemic hemolytic uremic syndrome
CD46/ FACTOR H/ FACTOR I
Dissociates C1r and C1s from C1q
C1 inhibitor
Proteolytically cleaves C3b And C4b
Factor I
Cofactor of factor I to inactivate C3b
Prevents binding of B to C3b
Factor H
Cofactor of factor I to inactivate C4b
C4-binding protein
Increases the dissociation of C3 convertase:
DAF
Membrane Inhibitor of Reactive (MIRL);
Inhibits Formation of MAC
CD59
Prevents attachment of C5b67 to cell membrane
S protein (vitronectin)
CLASSICAL PATHWAY:
Binds to Fc of IgM or IgG
C1q
CLASSICAL PATHWAY:
Activate C1s
C1r
CLASSICAL PATHWAY:
Cleaves C4 and C2
C1s
CLASSICAL PATHWAY:
Key intermediate (all pathways)
C3
CLASSICAL PATHWAY:
Initiates MAC
C5
CLASSICAL PATHWAY:
Starts pore formation
C8
CLASSICAL PATHWAY:
Polymerizes to cause cell lysis
C9
ALTERNATIVE PATHWAY:
Binds C3b To Form C3 Convertase
Factor B
ALTERNATIVE PATHWAY:
Cleaves Factor B
Factor D
ALTERNATIVE PATHWAY:
Stabilizes C3 convertase
Factor P or Properdin
LECTIN PATHWAY:
Binds to Mannose
MBL
LECTIN PATHWAY:
Helps cleave C4 and C2
MASP-1
Cleaves C4 and C2
MASP-2
