Inflammation Drugs

Question 1

NSAIDs

Answer 1

• prostaglandin production inhibitor = COX inhibitor
• MOA: prevent prostaglandin production by inhibiting COX1, anti-inflammatory, analgesic, antipyretic
• indication: mild pain (analgesic) –> sprains, strains, muscle pain, toothache, HA; fever; inflammation –> OA, RA, gouty arth, Lupus, dysmenorrhea

Contraindication: pregnancy (class D), PUD, RF, bleeding, concurrently with ETOH

• black box warning (twice): sudden death, MI, unstable angina, ischemic CVA, TIA and peripheral thrombosis

Question 2

NSAID-Aspirin

Answer 2

• MOA: antiplatelet: small scheduled dose (MI, CVA, prophylaxis)
• contraindication: <19 years of age (Reye’s syndrome–swelling of liver and brain)

Question 3

glucocorticoids

Answer 3

prednisone, methylprednisone

• indication: inflammatory disorders
• contraindication: fungal/viral infections, live attenuated virus vaccine (intranasal flu, small pox)
• routes: PO, IM, topical, aerosol, intra-articular injection
• SE: slide18

Question 4

DMARD

Answer 4

methotrexate, hydroxychloroquine, azathioprine, cyclosporine, tacrolimus

• indication: slow progression of autoimmune disorder, peak effect 3-6 weeks
• contraindication: never during acute infection

Question 5

DMARD-methotrexate

Answer 5

• MOA: immunomodulator, cytotoxic agent, bone marrow suppression
• contraindication: pregnancy (teratogenic), lactation, pediatrics

Question 6

DMARD-hydroxychloroquine

Answer 6

• MOA: antimalarials, anthelmintic

- SE: EYES

Question 7

DMARD- azathioprine, cyclosporine, tacrolimus

Answer 7

• MOA: immunosupressants, given for organ transplants

- SE: organs, physical

Question 8

Anti-gout - colchicine

Answer 8

PO

• MOA: anti-inflammatory ONLY FOR GOUT
• SE: GI distress, suppressed bone marrow, rhabdomyolysis
• contraindication: pregnancy (C)

Question 9

Anti-gout - allopurinol

Answer 9

PO/IV

• MOA: lowers serum uric acid biosynthesis
• SE: organs
• contraindication: pregnancy (C)