Antiulcer Drug

Question 1

antacid

Answer 1

calcium, carbonate (chew), magnesium hydroxide (suspension/tablet), magnesium hydroxide/aluminum hydroxide (suspension, tab)

• MOA: neutralize HCl acid, decrease pesin activity, promote healing, decrease inflammation, antagonist to ETOH

no constipation or diarrhea

Question 2

h2 blocker

Answer 2

famtodine (IV/PO), cimetidine (IV/PO), nizatidine (PO)

• MOA: reduce gastric acid by blocking H2 receptor on stomach, promote healing of ulcer
• SE: Genital, CNS, GI

Question 3

proton pump inhibitor

Answer 3

pantoprazole (IV/PO), omeprazole (PO)

• MOA: reduce gastric acid, oral peak effect after several days
• SE: GI, brain, physical, organ

Question 4

pepsin inhibitor

Answer 4

sucralfate (PO)

• MOA: reacts with gastric acid and forms a paste, adheres to ulcer protecting it
• SE: constipation, hyperglycemia