Hematopoietic and Anticancer Drugs

Question 1

Epoetin alpha

Answer 1

increase RBC

MOA:
- erythropoietin growth factor

Indication:

• low RBC secondary to CKD
• replacement of blood cells after chemo and HIV drug
• hasting of bone marrow function after a bone marrow transplant

SE:

• HTN
• increased H&H
• low iron and B12

AE:
- seizure, thromboembolic event

Contraindication

• pregnancy
• uncontrolled HTN

Question 2

filgrastim

Answer 2

specific to neutrophils and WBC

MOA:
- leukopoietic growth factor

Indication:

• neutropenia from antineoplastic drugs, HIV, neonatal neutropenia (prevent infection)
• increase WBC prior to harvesting (autologous transplant)

SE:

• bone/joint/muscle pain
• leukocytosis absolute neutrophil > 10,000

AE:
- splenomegaly/rupture

Contraindication:
- pregnancy (C)

Question 3

oprelvekin

Answer 3

platelets

MOA:
- thrombopoietic growth factor

Indication:
- chemotherapy-induced thrombocytopenia

AE:
- fluid retention and HF
- tachydysrhythmia 
- MI
- conjunctival injection
papilledema

Contraindication
- pregnancy