INFECTIOUS DISEASES (VIRAL INFECTIONS)

Question 1

________ is a acute viral infections that affects multiple organs and causes a wide range of disease from mild, self-limited infections to severe systemic manifestations

Answer 1

measles

Question 2

measles virus is a single stranded RNA virus of the ________– family

Answer 2

paramyxoviridae family

Question 3

Measles Morphology

ulcerated mucosal lesions in the oral cavity near the opening of the stensen ducts (the pathognomonic ________) are marked by necrosis, neutrophilic exudate, and neurovascularization

Answer 3

koplik spots

Question 4

Measles Morphology

the large lymphoid organs typically have marked follicular hyperplasia, large germinal centers and randomly distributed multinucleate giant cells called ______________

Answer 4

Warthin-Finkeldley cells

Question 5

___________ is an acute systemic viral infection usually associated with pain and swelling of the salivary glands

Answer 5

mumps

Question 6

MORPHOLOGY OF MUMPS

___________ is bilateral in 70% of cases, the affected glands are enlarged, have a doughy consistency, and are moist, glistening-and reddish brown on cross section.

Answer 6

mumps parotitis

Question 7

MORPHOLOGY OF MUMPS

in ____________, testicular swelling may be marked caused by edema, mononuclear cell infiltration, and focal hemorrhages

Answer 7

mumps orchitis

Question 8

MORPHOLOGY OF MUMPS

_________ is associated with perivenous demylenitation and perivascular monuclear cuffing

Answer 8

mumps encephalitis

Question 9

______________ causes an acute systemic viral infection, leading to a wide range of manifestations, from mild, self-limited infections to paralysis of limb muscles and respiratory muscles

Answer 9

poliomyelitis

Question 10

______________ causes an acute systemic infection that has very two very different presentations: a mild self limited infection or neuroinvasive disease associated with long term neurologic sequelae

Answer 10

west nile virus infections

Question 11

_____________ is a severe life threatening multisystem syndrome in which there is a vascular damage leading to widespread hemorrhage and shock

Answer 11

viral hemorrhagic fever

Question 12

___________ is a flavivirus that was discovered in 1947 and was subsequently found to be widespread in africa, asia and middle east

common findings in newborn children include microcephaly, ventriculomegaly, and congenital joint contractures and pulmonary hypoplasia

Answer 12

zika virus

Question 13

___________ is a flavivirus transmitted by Aedes mosquitoes in tropical and subtropical regions

clinical manifestations:
headache
macular rash
severe myalgias
hemorrhagic fever with bleeding
plasma leakage leading to shock and respiratory distress

Answer 13

dengue

Question 14

_____________ called COVID 19 was first detected in wuhan china and was reported to WHO in december 2019.

clinical manifestations ranged from mild to severe respiratory illness

Answer 14

SARS-CoV 2

Question 15

___________ is defined as the persistence of viral genomes in cells that do not produce infectious virus

Answer 15

Latency infections
(Herpesvirus infections)

Question 16

SUBGROUPS OF HUMAN HERPESVIRUSES

________ including HSV-1, HSV-2 and VSV infect epithelial cells and produce latent infection in postmitotic neurons

Answer 16

alpha group viruses

Question 17

SUBGROUPS OF HUMAN HERPESVIRUSES

_________ including CMV and human herpes viruses 6 and 7 which infect and produce latent infection in a variety of cell types

Answer 17

Beta group viruses

Question 18

SUBGROUPS OF HUMAN HERPESVIRUSES

____________ including EBV AND Kaposi sarcoma associated virus produce latent infection mainly in lympoid cells

Answer 18

gamma virus

Question 19

SUBGROUPS OF HUMAN HERPESVIRUSES

_________ is an old world monkey virus that resembles HSV-1 can cause fatal neurologic disease in animal handlers usually resulting from an animal bite

Answer 19

herpesvirus simiae

Question 20

acute infection with ______________ causes chicken poxes and reactivation of latent _________ causes shingles (also called herpes zoster)

Answer 20

varicella zoster virus

Question 21

________ occurs when varicella zoster virus that has long remained latent in the dorsal root ganglia after a previous chickenpox infection is reactivated and infects sensory nerves that carry it to one or more dermatomes

Answer 21

shingles

Question 22

________ a beta group herpesvirus can produce a variety of disease manifestations, depending on the age of the host and more importantly on the host’s immune status

Answer 22

cytomegalovirus infections

Question 23

_________ causes infectious mononucleosis, a benign, self limited lumphoproliferative disorder, and is associated with the pathogenesis of several human tumors most commonly certain lymphomas and nasopharingeal carcinoma

Answer 23

epstein barr virus