ENVIRONMENTAL DISEASES II

Question 1

two drugs that most frequently cause adverse reactions reported to the US food and drug administration are the oral anticoagulants _______ and _______

Answer 1

warfarin
dabigatran

Question 2

most common type of _________ (previously referred to as hormone replacement therapy) consists of administration of estrogens together with progestagen

Answer 2

Menopausal Hormone Therapy

Question 3

MHT risk/benefit consensus summarized

combination ______ increases the risk of breast cancer after a median time of 5-6 years

Answer 3

estrogen progestin

Question 4

MHT risk/benefit consensus summarized

may have have a protective effect on the development of _______ and ____ in women younger than 60 yrs.

Answer 4

atherosclerosis and coronary disease

Question 5

MHT risk/benefit consensus summarized

MHT increases the risk of _ and ___ including deep vein thrombosis and pulmonary embolism

Answer 5

stroke and VTE

Question 6

If acetaminophen is taken in large doses unconjugated ________ accumulates and causes hepatocellular injury, leading to centrilobular necrosis, that may progress to liver failure

Answer 6

NAPQI
N-acetyl-P-benzoquineimine

Question 7

aspirin

acute ________overdose causes alkalosis as a consequence of the stimulation of the respiratory center in the medulla

Answer 7

acute salicylate overdose

Question 8

cocaine facilitates neurotransmission both in the CNS where it blocks the reuptake of ______ and at ______ nerve endings, where it blocks the reuptake of both ______ and _______- while stimulating the presynaptic release of norepinephrine

Answer 8

dopamine and adrenergic nerve endings
epinephrine and norepinephrine

Question 9

cocaine

CNS: the most common acute effects on the CNS are ________

Answer 9

hyperpyrexia