Infectious Diseases I: Tetracyclines Flashcards
Tetracyclines MOA
inhibit protein synthesis by reversibly binding to 30S ribosome
general coverage of Tetracyclines
Many Gram+: staph strep entercocci Gram -: Haemophilus moraxella Unique pathogens: spirochetes Rickettsiae
Minocycline is usually preferred in what type of infections
Skin infections, including acne
Doxycycline brand names (6)
Acticlate Adoxa Doryx Monodox (doxycycline monohydrate) Oracea Vibramycin (doxy hycalate)
Should doxycycline be taken with or without food?
Take w/ food to reduce GI upset
EXCEPT
Oracea 40 mg take 1 hr before or 2 hrs after meal
Tetracyclines warnings
Do not use in kids < 8 (suppress bone growth, perm discolor teeth)
do not use in pregnancy/breastfeeding
Photosensivity
severe skin reactions
Drug induced lupus erythematosus (minocylcine)
Tetracyclines side effects
n/v/d
rash
severe skin reactions (SJS/TEN)
photosensitivity
Minocycline brands
Minocin
Solodyn
Monolira
Minocycline renal dosing
CrCl < 80
Max 200 mg/day
Tetracycline dosing
250-500 mg q6h
Adjustment needed for crcl < 50
Tetracycline should be taken with food (t/f)
FALSE
IV:PO conversion for doxy/minocycline
1:1
Tetracycline is used what particular infection?
H. pylori
Tetracyclines can be used for treat some MRSA skin infections (t/f)
TRUE
Infections that can be treated with doxy
Lyme disease Rocky mountain spotted fever CAP COPD exacerbation VRE UTI Chlamydia gonorrhea (combo therapy)
