Alzheimer's Disease

Question 1

Possible reversible causes of dementia

Answer 1

B12 deficiency
depression
infection

Question 2

Mini mental state exam score of ____ indicates a memory disorder

Answer 2

< 24

Question 3

Drugs that can worsen dementia

Answer 3

Antihsitamines, antiemetics (anticholinergic)
antipsychotics
barbiturates
BZDs
Anticholingerics
Muscle relaxants
CNS depressants

Question 4

Natural products used to treat dementia

Answer 4

Vitamin E 
Ginkgo biloba (incr bleed risk)
Vitamin D (if levels are low)

Question 5

Number of patients that experience symptom relieve from drug treatment

Answer 5

1 out of 12

However, drug treatment dose slow disease progression

Question 6

Mainstay of alzhiemer’s treatment

Answer 6

Acetylcholinesterase inhibitors

+/- memantine

Question 7

Aricept

Answer 7

donepezil

5, 10, 23 mg tabs

Question 8

Main side effects of achetylcholinesterase inhibitors

Answer 8

n/v/d (take HS to combat nausea)

Bradycardia, fainting, insomnia

Question 9

Exelon

Answer 9

Rivastigmine

Available as cap, patch

Question 10

Exelon cap dosing

Answer 10

1. 5 mg BID (breakfast and dinner)

1. 5- 6 mg BID

Question 11

Exelon patch dosing

Answer 11

4.6 mg patch daily
max 13.3 mg daily (4.6 mg w/ hepatic impairment)

patch has less GI side effects, but incr cost

Question 12

Razadyne

Answer 12

galantamine

Ir tab, er tab, solution

Question 13

Razadyne dosing

Answer 13

4 mg BID
4-12 mg BID
preferred to take w/ food

Question 14

Namenda MOA

Answer 14

NMDA antagonist; blocks glutamate

Question 15

Namzaric

Answer 15

donepezil/memantine xr

7/10 mg, 14/10, 21/10, 28/10

Question 16

Namenda side effects

Answer 16

dizziness
constipation
HA

Question 17

Namenda renal dosing

Answer 17

CrCl < 30
5 mg IR BID
14 mg XR daily

Question 18

Acethycholinesterase inhibitors that cause QT prolongation

Answer 18

donepzil

galantamine