Alzheimer's Disease Flashcards

1
Q

Possible reversible causes of dementia

A

B12 deficiency
depression
infection

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2
Q

Mini mental state exam score of ____ indicates a memory disorder

A

< 24

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3
Q

Drugs that can worsen dementia

A
Antihsitamines, antiemetics (anticholinergic)
antipsychotics
barbiturates
BZDs
Anticholingerics
Muscle relaxants
CNS depressants
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4
Q

Natural products used to treat dementia

A
Vitamin E 
Ginkgo biloba (incr bleed risk)
Vitamin D (if levels are low)
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5
Q

Number of patients that experience symptom relieve from drug treatment

A

1 out of 12

However, drug treatment dose slow disease progression

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6
Q

Mainstay of alzhiemer’s treatment

A

Acetylcholinesterase inhibitors

+/- memantine

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7
Q

Aricept

A

donepezil

5, 10, 23 mg tabs

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8
Q

Main side effects of achetylcholinesterase inhibitors

A

n/v/d (take HS to combat nausea)

Bradycardia, fainting, insomnia

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9
Q

Exelon

A

Rivastigmine

Available as cap, patch

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10
Q

Exelon cap dosing

A
  1. 5 mg BID (breakfast and dinner)

1. 5- 6 mg BID

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11
Q

Exelon patch dosing

A

4.6 mg patch daily
max 13.3 mg daily (4.6 mg w/ hepatic impairment)

patch has less GI side effects, but incr cost

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12
Q

Razadyne

A

galantamine

Ir tab, er tab, solution

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13
Q

Razadyne dosing

A

4 mg BID
4-12 mg BID
preferred to take w/ food

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14
Q

Namenda MOA

A

NMDA antagonist; blocks glutamate

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15
Q

Namzaric

A

donepezil/memantine xr

7/10 mg, 14/10, 21/10, 28/10

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16
Q

Namenda side effects

A

dizziness
constipation
HA

17
Q

Namenda renal dosing

A

CrCl < 30
5 mg IR BID
14 mg XR daily

18
Q

Acethycholinesterase inhibitors that cause QT prolongation

A

donepzil

galantamine