Infectious Diseases I: Background Flashcards

1
Q

Gram + stain

A

dark purple of bluish

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2
Q

Gram - stain

A

Pink or reddish

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3
Q

Gram + cocci in clsuters

A

Staphylococcus

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4
Q

Gram + cocci in pairs and chains

A

Strep pneumoniae (pairs)
Strep
Enterococcus

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5
Q

Gram - cocci

A

Neisseria

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6
Q

Gram - rods

A
E. Coli
Klebsiella
Enterobacter
Proteus
Pseudomonas
H. influenzae
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7
Q

Define “breakpoints”

A

The usual drug conc that inhibits growth of a bacteria

determined by Clinical & Lab Standards institute

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8
Q

Susceptible means….

A

The MIC = to the breakpoint

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9
Q

Antibiogram

A

provides susceptibility patterns at a certain institution over a certain period of time

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10
Q

Common resistant pathogens

A
S. aureus (MRSA)
Entercoccus (VRE)
E. Coli (ESBL, CRE)
K. pneumoniae (ESBL,CRE)
Pseudomonas
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11
Q

primary resistance mechanism of B-lactams

A

enzyme inactivation

Beta-lactamase

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12
Q

Cell wall inhibitors

A
Beta lactams
Monobactams (aztreonam)
Vanco
dalbavancin
telavancin
oritavancin
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13
Q

Protein synthesis inhibitors

A
AG's
macrolides
tetracyclines
clindamycin
Linezolid, tedizolid
Quinupristin/dalfopristin
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14
Q

Cell membrane inhibitors

A

Polymyxin
daptomycin
telavancin
oritavancin

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15
Q

DNA/RNA inhibitors

A

quinolones
metronidazole
rifampin

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16
Q

Folic acid synthesis inhibitors

A

Sulfonamides
trimethoprim
dapsone

17
Q

Hydrophillic agents

A

beta lactams
AG’s
Daptomycin
glycopeptides (vanco?)

18
Q

Lipophillic agents

A
quinolines
macrolides
rifampin
linezolid
tetracyclines
19
Q

Hydrophillic antibiotic characteristics

A

poor tissue penetration
nephrotoxic
Not active against atypical bacteria (can’t get inside cell)
Might need loading dose for serious illness

20
Q

Lipophilic antibiotic characteristics

A
good tissue penetration
Hepatotoxicity
DDIs
active against atypical pathogens
PO to IV ratio usually 1:1
21
Q

Time-dependent antibiotics

A

beta lactams
Time > MIC
Dose frequently, extended infusions, continuous infusions

22
Q

Conc-dependent antibiotcs

A

AG’s
FQ’s
daptomycin
Cmax:MIC