Infectious Diseases I: Background Flashcards
Gram + stain
dark purple of bluish
Gram - stain
Pink or reddish
Gram + cocci in clsuters
Staphylococcus
Gram + cocci in pairs and chains
Strep pneumoniae (pairs)
Strep
Enterococcus
Gram - cocci
Neisseria
Gram - rods
E. Coli Klebsiella Enterobacter Proteus Pseudomonas H. influenzae
Define “breakpoints”
The usual drug conc that inhibits growth of a bacteria
determined by Clinical & Lab Standards institute
Susceptible means….
The MIC = to the breakpoint
Antibiogram
provides susceptibility patterns at a certain institution over a certain period of time
Common resistant pathogens
S. aureus (MRSA) Entercoccus (VRE) E. Coli (ESBL, CRE) K. pneumoniae (ESBL,CRE) Pseudomonas
primary resistance mechanism of B-lactams
enzyme inactivation
Beta-lactamase
Cell wall inhibitors
Beta lactams Monobactams (aztreonam) Vanco dalbavancin telavancin oritavancin
Protein synthesis inhibitors
AG's macrolides tetracyclines clindamycin Linezolid, tedizolid Quinupristin/dalfopristin
Cell membrane inhibitors
Polymyxin
daptomycin
telavancin
oritavancin
DNA/RNA inhibitors
quinolones
metronidazole
rifampin