Infectious Diseases I: Quinolones

Question 1

Quinolones MOA

Answer 1

inhibit DNA topoisomerase IV and DNA gyrase with inhibits DNA synthesis of bacteria

Question 2

Quinolones exhibit ______ dependent killing

Answer 2

concentration

Question 3

Respiratory Quinolones include:

Answer 3

gemifloxacin
levofloxacin
moxifloxacin

due to enhanced coverage of S. pneumoniae and atypical pathogens

Question 4

Quinolones that cover pseudomonas

Answer 4

ciprofloxacin

levofloxacin

Question 5

Quinolones with enhanced gram + coverage and anaerobic coverage

Answer 5

moxifloxacin

Question 6

Quinolone with MRSA coverage

Answer 6

delafloxacin

approved for skin infections

Question 7

Main warnings with Quinolones

Answer 7

tendon inflammation and rupture
peripheral neuropathy
CNS effects (tremor, confusion, seizures)
QT prolongation
photosensitivity
Hypo-/hyperglycemia

Question 8

Which Quinolone has the highest risk of qt prolongation?

Answer 8

moxifloxacin

Question 9

Why is moxifloxacin not used for UTIs?

Answer 9

doesn’t achieve adequate conc in the urine

Question 10

All Quinolones require renal dose adjustments except for….

Answer 10

moxifloxacin

Question 11

Cipro eye drops brand

Answer 11

Ciloxin

Question 12

Cipro ear drops brand

Answer 12

Cetraxal

Question 13

LEvofloxacin eye drops brand

Answer 13

Quixin

Question 14

Moxifloxacin eye drops brands

Answer 14

Moxeza

Vigamox

Question 15

Baxdela

Answer 15

delafloxacin
450 mg PO q 12h
300 mg IV q12h

Question 16

Gatifloxacin

Answer 16

Zymaxid

Only available as eye drops

Question 17

What form of Cipro cannot be given via feeding tube?

Answer 17

cipro oral suspension

Cipro tabs can be crushed and mixed with water and given via feeding tube

Question 18

Phosphate binders (lanthanum and sevelamer) Incr/decr levels of Quinolones

Answer 18

decrease
take 2 hrs before/after lanthanum
take 2 hrs before/ 6 hrs after taking sevelamer