Infectious Disease II Pt. 2

Question 1

If a patient has latent TB how long is there treatment usually

Answer 1

3 or 4 months

Question 2

For latent TB what are the three possible regimens

Answer 2

Isoniazid and Rifapentine once weekly for 3 months
Rifampin 600 mg for 4 months
Isoniazid with Rifampin for 3 months

Question 3

What is the preferred regimen for a patient pregnant who has LATENT TB

Answer 3

Isoniazid for 9 months

Question 4

What is the preferred Rifamycin if the patient has HIV with ART

Answer 4

Rifapentine or rifabutin

Question 5

If a patient has ACTIVE TB what is the regimen and how long is it (HINT: RIPE/INTENSIVE PHASE)

Answer 5

R: rifampin
I: Isoniazid
P: Pyrazinamide
E: Ethambutol
Duration is 8 weeks- TWO MONTHS

Question 6

If a patient has ACTIVE TB what is the regimen and how long is it

Answer 6

Isoniazid PLUS Rifampin

Question 7

T/F: M. Tuberculosis is acid fast bacilli (AFB)

Answer 7

True

Question 8

What drugs used to treat tuberculosis are associated with hemolytic anemia

Answer 8

Rifampin and Isoniazid (detected through positive coombs test)

Question 9

What are the adverse effects of rifampin

Answer 9

Increased LFTs, orange-red discoloration of body fluids

Question 10

What are the adverse effects of Isoniazid

Answer 10

Heptitis, Peripheral neuropathy, Drug Induced Lupus Erythematosus

Question 11

T/F: Pyrazinamide is associated with acute gout and increased LFTs

Answer 11

True

Question 12

T/F: Ethambutol is associated with OPTIC NEURITIS (dose related), confusion and hallucinations

Answer 12

True

Question 13

T/F: Rifampin is an enzyme INHIBITOR

Answer 13

False: Rifampin is an enzyme INDUCER

Question 14

Which anticoagulants should be avoided with rifampin use

Answer 14

Warfarin, Apixaban, and Rivaroxaban

Question 15

If a patient is getting infective endocarditis dental prophylaxis what should the antibiotics be

Answer 15

Amoxicillin 2 grams 30 to 60 mins before a dental procedure

PCN Allergy: Clindaymcyin OR Azithromycin or Clarithromycin

Question 16

If a patient has skin infections what is the the first line if there is no purulence, purulence/PCN allergy

Answer 16

Cephalexin (Keflex)

Bactrim DS, Doxycycline 100

Question 17

For severe skin and soft tissue infections with SEVERE PURULENCE what are the available options, for necrotizing fascitis

Answer 17

VAncomycin, DAptomycin, and Linezolid (MRSA coverage),

Vancomycin and Pip/tazo or meropenem

Question 18

If someone has complicated UTI what is the antibiotic of choice

Answer 18

Carbapenem

Question 19

What type of penicllin should be given for Syphillis

Answer 19

Bicillin-LA ONLY

Question 20

What treatment can be given for HPV

Answer 20

Imiquimod cream (HPV vaccine is most effective)

Question 21

How long is active TB treated

Answer 21

Total 6 months (2 months active/4 drugs, 4 active/2 drugs)

Question 22

What are the drug options for pyelonephritis

Answer 22

Quniolones, bactrim

Question 23

What is SBP prophylaxis options

Answer 23

Bactrim or Ciprofloxacin