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NAPLEX STUDY STUFF > Autoimmune Conditions > Flashcards

Autoimmune Conditions Flashcards

1
Q

What are the two main steroids of the body, which regulates what

A

Cortisol and Aldosterone

Cortisol: regulates inflammation
Aldosterone: regulates a balance of water and electrolytes

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2
Q

What is the steroid that most mimics aldosterone

A

Fludrocortisone

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3
Q

T/F: Fludrocortisone is approved for use in Addison’s disease

A

True

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4
Q

What is Cushing’s syndrome

A

Too much cortisol made from the adrenal glands, or the amount of exogenous steroids is more than the body produces

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5
Q

What is addison’s disease

A

Not enough cortisol is being made

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6
Q

What are the two most potent systemic steroids

A

Betamethasone and Dexamethasone

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7
Q

What are the the 4 intermediate acting systemic steroids

A

Triamcinolone, Methylprednisolone, prednisolone, prednisone

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8
Q

What are the two short acting systemic steroids

A

Hydrocortisone and cortisone

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9
Q

T/F: Cortisone is the prodrug of cortisol

A

True

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10
Q

T/F: Prednisone is the prodrug of prednisolone

A

True

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11
Q

How does the medrol therapy pack work?

A

Gives a high dose initially to quickly reduce inflammation then taper the dose down to treat remaining inflammation without a rebound attack

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12
Q

What is a medrol therapy pack

A

21 x 4 mg tablets of methylprednisolone given over 6 days

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13
Q

How is day 1 of the medrol pack taken

A

2 tablets before breakfast, 1 tablet after lunch, 1 tablet after dinner, 2 tablets at bedtime

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14
Q

How is day 2 of the medrol pack taken

A

1 tablet before breakfast, 1 tablet after lunch, 1 tablet after dinner, 2 tablets at bedtime

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15
Q

How is day 3 of the medrol pack taken

A

1 tablet before breakfast, 1 tablet after lunch, 1 tablet after dinner, 1 tablet before bedtime

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16
Q

How is day 4, 5, and 6 of the medrol pack taken

A

Day 4: 1 tablet before breakfast, 1 tablet after lunch, 1 tablet before bedtime
Day 5: 1 tablet before breakfast, 1 tablet before bedtime
Day 6: 1 tablet before breakfast

17
Q

What are the risk of strong immunsupression

A

Increased risk of tuberculos and hepatitis B and C (must treat prior to start of immunosuppresive drugs)
Viruses
Lymphomas and skin cancers
Infections

18
Q

What is the initial therapy for Rheumatoid Arthritis, how should it be given

A

Methotrexate

7.5 to 20 mg a week (NOT DOSED DAILY)

19
Q

What are the TNF-inhibitors

A

Etanercept (Enbrel)
Adalimumab (Humira)
Infliximab (Remicade)
Golimumab (Simponi)

20
Q

What are the DMARDs used in RA

A

Methotrexate, Hydroxychloroquine, Leflunamide

21
Q

Which DMARDS cannot be used in pregnancy

A

Methotrexate and Leflunamide

NAPLEX STUDY STUFF (45 decks)

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