Anticoagulation Flashcards
What factors does Warfarin inhibit
2, 7, 9, 10
What is the dose for blood clot prevention for Heparin
5000 units SC every 8 to 12 hours
What is the dose for VTE treatment using Heparin
80 units/kg for bolus, 18 units/kg/hr infusion
What is the reversal agent for Heparin and LMWH
Protamine
What is the dose for blood clot prevention for Enoxaparin
30 mg SQ every 12 hours OR 40 mg SC once daily
What is the treatment dose of an ACS/STEMI using Heparin
60 units/Kg IV bolus OR infuse 12 units kg/hr
What is the dose for VTE/UA/NSTEMI treatment using Enoxaparin
1 mg/kg SC every 12 hours OR 1.5 mg/kg SC daily for inpatient VTE treatment
What is the dose for STEMI treatment when using enoxaparin
30 mg IV bolus PLUS 1 mg/kg SC dose
How do you monitor Enoxaparin
Anti-Xa levels (4 hours after the peak)
What patients are prime for LMWH
Morbidly obese and pregnant patients
What drugs can be given if the the patient develops HIT
Direct Thrombin Inhibitors: Argatroban (injectable) and Dabigatran (oral)
When can warfarin be restarted after HIT
Platelets are above 150,000
If a patient has Afib what should the dose of apixaban be
5 mg BID
When should the dose of apixaban be lowered, what is the appropiate dose
Age greater than 80, weight less than 60 kg, and Scr is greater than 1.5// 2.5 mg BID
What is the treatment dose of VTE/PE using apixaban
10 mg BID for 7 days, then 5 mg BID
What are the treatment doses using rivaroxaban for AFIB
CrCl greater than 50: 20 mg daily WITH evening meal
CrCl between 50 and 15: 15 mg daily with evening meal
CrCl less than 15: Don’t use
What is the treatment dose of VTE
15 mg BID with food for 21 days THEN 20 mg daily with food
CrCl less than 30: avoid use
What is the reversal agent for Apixaban and Rivaroxaban
Andexxa (andexant Alfa)
What is the antidote for Dabigatran (Pradaxa)
Idarcrizumab
What class is Dabigatran (Pradaxa)
Oral Direct FactorIIa Inhibitor
What does Kcentra contain, how should it be administered
Protein C and S, Clotting factors II, VII, IX, X// With vitamin K
If a patient has gone through cardioconversion for Afib how long should a patient take anticoagulation
4 weeks
How many mg of protamine reverses how many units of Heparin
1 mg = 100 units
What vitamin is known to increase INR
Vitamin E
If a patient’s INR is stable what is interval can the INR be tested
Every 12 weeks
If a patient is taking warfarin but is having major surgery when should the warfarin be stopped
5 days prior
