Anticoagulation

Question 1

What factors does Warfarin inhibit

Answer 1

2, 7, 9, 10

Question 2

What is the dose for blood clot prevention for Heparin

Answer 2

5000 units SC every 8 to 12 hours

Question 3

What is the dose for VTE treatment using Heparin

Answer 3

80 units/kg for bolus, 18 units/kg/hr infusion

Question 4

What is the reversal agent for Heparin and LMWH

Answer 4

Protamine

Question 5

What is the dose for blood clot prevention for Enoxaparin

Answer 5

30 mg SQ every 12 hours OR 40 mg SC once daily

Question 6

What is the treatment dose of an ACS/STEMI using Heparin

Answer 6

60 units/Kg IV bolus OR infuse 12 units kg/hr

Question 7

What is the dose for VTE/UA/NSTEMI treatment using Enoxaparin

Answer 7

1 mg/kg SC every 12 hours OR 1.5 mg/kg SC daily for inpatient VTE treatment

Question 8

What is the dose for STEMI treatment when using enoxaparin

Answer 8

30 mg IV bolus PLUS 1 mg/kg SC dose

Question 9

How do you monitor Enoxaparin

Answer 9

Anti-Xa levels (4 hours after the peak)

Question 10

What patients are prime for LMWH

Answer 10

Morbidly obese and pregnant patients

Question 11

What drugs can be given if the the patient develops HIT

Answer 11

Direct Thrombin Inhibitors: Argatroban (injectable) and Dabigatran (oral)

Question 12

When can warfarin be restarted after HIT

Answer 12

Platelets are above 150,000

Question 13

If a patient has Afib what should the dose of apixaban be

Answer 13

5 mg BID

Question 14

When should the dose of apixaban be lowered, what is the appropiate dose

Answer 14

Age greater than 80, weight less than 60 kg, and Scr is greater than 1.5// 2.5 mg BID

Question 15

What is the treatment dose of VTE/PE using apixaban

Answer 15

10 mg BID for 7 days, then 5 mg BID

Question 16

What are the treatment doses using rivaroxaban for AFIB

Answer 16

CrCl greater than 50: 20 mg daily WITH evening meal
CrCl between 50 and 15: 15 mg daily with evening meal
CrCl less than 15: Don’t use

Question 17

What is the treatment dose of VTE

Answer 17

15 mg BID with food for 21 days THEN 20 mg daily with food

CrCl less than 30: avoid use

Question 18

What is the reversal agent for Apixaban and Rivaroxaban

Answer 18

Andexxa (andexant Alfa)

Question 19

What is the antidote for Dabigatran (Pradaxa)

Answer 19

Idarcrizumab

Question 20

What class is Dabigatran (Pradaxa)

Answer 20

Oral Direct FactorIIa Inhibitor

Question 21

What does Kcentra contain, how should it be administered

Answer 21

Protein C and S, Clotting factors II, VII, IX, X// With vitamin K

Question 22

If a patient has gone through cardioconversion for Afib how long should a patient take anticoagulation

Answer 22

4 weeks

Question 23

How many mg of protamine reverses how many units of Heparin

Answer 23

1 mg = 100 units

Question 24

What vitamin is known to increase INR

Answer 24

Vitamin E

Question 25

If a patient’s INR is stable what is interval can the INR be tested

Answer 25

Every 12 weeks

Question 26

If a patient is taking warfarin but is having major surgery when should the warfarin be stopped

Answer 26

5 days prior