Infection 7 - Blood-borne Viruses Flashcards

1
Q

Why is HIV ignored by our immune system?

A

It’s outer membrane is a human bilayer due to viral budding after replication within a human cell. Our immune systems recognise this bilayer as self.

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2
Q

Which cells does HIV infect and replicate within?

A

CD4+ T cells

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3
Q

What is the normal range for serum CD4+ count?

A

500 - 1500 / mm^3 blood

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4
Q

At what point does HIV cause AIDS?

A

When CD4+ count drops below 200 / mm^3 blood

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5
Q

What is the leading cause of death of HIV patients?

A

Tuberculosis

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6
Q

What are common symptoms of mild HIV infection?

A
  • Fever
  • Chills
  • Rash / recurrent skin infection
  • Aches
  • Sore throat
  • Fatigue
  • Mouth ulcers
  • Lymphadenopathy
  • Kaposi sarcoma
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7
Q

List some ways HIV may be transmitted between people:

A
  • Sexual (vaginal/anal/oral)
  • Sharing needles
  • Childbirth
  • Breast-feeding
  • Needlestick injury
  • Medical procedures (blood transfusion, organ donation)
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8
Q

What is the treatment for HIV?

A
2 x NRTI (nucleoside RT inhibitor)
1 of:
- NNRTI
- Protease inhibitor
- Integrase inhibitor
- CCRS inhibitor
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9
Q

How many types of hepatitis are there?

A

5:

A, B, C, D, E

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10
Q

Which types of Hepatitis can be transferred by faecal-oral route only?

A

A + E

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11
Q

Which types of Hepatitis can be transferred by blood or sex?

A

B, C, D

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12
Q

Which types of Hepatitis can be transferred vertically?

A

B + D

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13
Q

What are the symptoms of acute hepatitis B?

A
  • Jaundice
  • Fatigue
  • Abdominal pain
  • Anorexia
  • Nausea
  • Vomiting
  • Arthralgia
    MOST ASYMPTOMATIC
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14
Q

Acute Hepatitis B infection usually clears in what time frame?

A

Within 6 months

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15
Q

What percentage of people with an acute Hepatitis B infection will become chronically ill with hepatitis?

A

6 - 10%

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16
Q

What are the complications associated with chronic hepatitis B infection?

A
  • Cirrhosis

- Hepatocellular carcinoma

17
Q

What is the treatment for chronic Hepatitis B?

A

Lifelong anti-virals

18
Q

Vaccinations are available against which Hepatitis viruses?

A

A + B

19
Q

The presence of which antigen in the blood causes Hepatitis B to be infective?

A

E-antigen (HBeAg)

20
Q

What percentage of people with acute Hepatitis C infection will become chronically ill with hepatitis?

A

~ 80%

21
Q

What are the symptoms of chronic Hepatitis C?

A

Due to chronic liver disease/cirrhosis:

  • Fatigue
  • Weight loss
  • Blood clotting problems
  • Ascites
  • RUQ pain
  • Jaundice
22
Q

What is the treatment for chronic Hepatitis C?

A

Antiviral dual therapy 8-12 weeks

23
Q

What is the cure rate of individuals treated for chronic Hepatitis C?

A

> 90%