Infection 5 - Adaptive Immune System Flashcards
Where are antigen presenting cells located in the body?
- Skin
- Mucous membranes
- Lymphoid organs
- Blood
Where are dendritic cells found in the body?
- Lymph nodes
- Mucous membranes
- Blood
What cells can dendritic cells present antigens to?
- T cells
- B cells
Where are Langerhans’ cells found in the body?
Skin
What cells can Langerhans’ cells present antigens to?
T cells
Where are B cells found in the body?
Lymphoid tissue
Which immune cells can present antigens to B cells?
Dendritic cells
What is another name used for Major Histocompatibility Complexes (MHC molecules)?
Human Leukocyte Antigens (HLA)
Where are Class I MHC molecules found, and what cells do they present peptides to?
- All nucleated cells
- CD8+ T-cells
Which class of MHC molecules present peptides from INTRAcellular microbes to T cells?
Class I
Which class of MHC molecules present peptides from EXTRAcellular microbes to T cells?
Class II
Where are Class II MHC molecules found, and what cells do they present peptides to?
- Dendritic cells, Macrophages, B cells
- CD4+ T-cells
Why is it better to have many, diverse MHC molecules, rather than a select few?
More, diverse MHC molecules mean a wider range of antigens/microbes can be presented to our immune system, protecting us against infectious disease.
How do CD8+ T-cells respond when peptides from intracellular microbes are presented to them?
Directly kill the cell via:
- Perforins
- Granzymes
Where do T cells mature?
Thymus
