Immunologic Therapies

Question 1

Targets B cells by crosslinking DNA inhibiting DNA replication. Used in treating Goodpasture’s.

Answer 1

Cyclophosphamide

Question 2

Inhibits TLRs and decreases acidity of lysosomes (retinal toxicity)

Answer 2

Hydroxychloroquine

Question 3

Anti-CD20 Ab. Located on B cells (does not delete plasma cells)–> leads to no Ab production

Answer 3

Rituximab

Question 4

Drug that fuses the extracellular domain of CTLA-4 & Fc region of IgG1. Binds to B7-1/2 and leads to T cell unresponsiveness. Used to manage RA.

Answer 4

Abatacept

Question 5

Anti-PD1

Answer 5

Nivolumab

Question 6

1st line pain reliever, possible hepatotoxicity, Minimal side effects.

Answer 6

Acetominophen

Question 7

IL-1R antagonist

Answer 7

Anakinra

Question 8

Blocks DHFR, increases adenosine and decreases inflammation

Answer 8

Methotrexate

Question 9

COX-1 inhibitors. GI, Renal, and inhibited platelet aggregation risk factors.

Answer 9

Ketorolac and Asprin

Question 10

COX-2 inhibitors; Cardiovascular risks.

Answer 10

Celecoxib and Diclofenac

Question 11

Drug that blocks IL-2 and is used for acute organ rejection.

Answer 11

Daclizumab (Zenapax)

Question 12

Inhibitor of nucleotide synthesis, Inhibits B and T proliferation, Ab synthesis, and NK cell activity. Given to Goodpasture’s syndrome patients

Answer 12

Azathioprine (Imuran)

Question 13

TNF inhibitors

Answer 13

a. Infliximab (Remicade)
b. Adalimumab (humira)
c. Etanercept (Enbrel)
d. Certolizumab (Cimzia)
e. Golimumab (Simponi)

Question 14

Ab against Fc portion of IgE. Aids in type I hypersensitivity reaction.

Answer 14

Omalizumab

Question 15

Anti-CTLA 4

Answer 15

Ipilimumab

Question 16

Anti-IL-6 Ab

Answer 16

Tocilizumab

Question 17

Inhibits formation of NFAT by blocking de-phosphorylation of P-NFAT by activated Calcineurin. Used in Stevens Johnson Syndrome

Answer 17

Tacrolimus/Cyclosporine

Question 18

Eliminates fetal RBCs from mom’s circulation

Turns off maternal B cells by cross-linking BCR & FcyRII

Answer 18

Rhogam

Question 19

Pyrimidine synthesis blocker and teratogen

Answer 19

Leflunomide

Question 20

Purine synthesis inhibitor

Answer 20

Azathioprine

Question 21

Increases liver production of C1 inhibitor, Treatment of HAE

Answer 21

Danazolol

Question 22

JAK inhibitor, Stops IL-2 autocrine loop that would lead to CD4+ proliferation, differentiation & functionality. Used in RA management

Answer 22

Tofacitinib (Xeljanz)