1.4.3 Acute Inflammation and Wound Healing I Flashcards
Does this wound appear to be health by first or second intention?
This wound is healing by primary intention. The epithelial layer is in contact with each other, and no significant vascularization
What is the darker red object in the bottom of the picture in the dermis? What will happen to this?
This is a small hematoma in the dermis. This will eventually shrink, macrophages will begin engulfing RBCs and shrink it.
How old would you estimate this scar to be and what histopathologic features allow you to estimate this?
Blue cells in the picture are macrophage and neutrophils. This wound is roughly 72 hours old.
What is the black arrow in this picture pointing to?
The pink strands are fibrin
What cytokines or growth factors are likely involved in proliferation of the epithelium?
Epidermal growth factors
What cytokines or growth factors are likely involved in the proliferation of the dermal connective tissue underlying the epithelium?
FGF and VEGF
Looking at this wound, how many weeks old would you say it is?
This injury is old and disgusting
What is the difference between acute and chronic inflammation?
Chronic inflammation is not a vascular reaction.
What complicating factors might have caused this wound to form in this patient?
Infection and non-union
What are the possible long-term complication of this wound?
Patient will likely need an amputation, or they can take oral antibiotics for the rest of their life to avoid amputation.
The edge where the epithelium ends is indicative of what?
This points to the edge of the skin ulcer
What are the flattened cells in this picture and what is their role? What other cells are prominent in this picture?
The flattened blue cells are fibroblasts which are laying down collagen (the pink strands). Other cells are neutrophils and macrophages.
Based in this image how old would you say this wound is?
This wound is old probably weeks old
How do you think this wound is healing, by regeneration or scarring?
It is healing by scarring
What are some of the methods used to increase the healing rate in these ulcers?
These can be treated with antibiotics and also the tissue needs to be away from the low pH acid for a little to allow healing. Proton pump inhibitors
What is this?
This is the edge of the ulcer right before it dives into a pit.
What is this?
A large thrombus in the duodenum
How would you describe the tissue in the base of an ulcer?
Granulation tissue. It has fibroblasts and collagen. Many capillaries and will heal by scarring.
