3.3.3 Serum Sickness Flashcards
How does C1q measure measure IC?
Radiolabeled C1q is used to bind to circulating immune complexes
What does a reduced CH50 indicate?
Reduced levels of classical and/or MAC components
In a person with an active immune response going on, why would C3 and C4 levels be reduced?
The production of immune complexes may reduce serum C3 and C4 levels
What is a chimeric Ab?
A chimeric antibody (cAb) is an antibody made by fusing the antigen binding region (variable domains of the heavy and light chains, VH and VL ) from one species like a mouse, with the constant domain (effector region) from another species such as a rabbit.
On what cells is CD20 most present?
Found only on Pre- and mature B cells
Serum sickness is an example of what type of hypersensitivity?
Type III
What is the immediate course of action to follow with a patient taking Rituximab that subsequently develops serum sickness?
Take them off of it and maybe give steroids
What happens to deposited immune complexes in serum sickness?
They are removed by phagocytes
What is serum sickness?
It is a type III hypersensitivity reaction, in which the person has developed an immune response against some type of therapy (Drugs, Mab, etc.)
What is being used to overcome diminish the possibility of serum sickness?
Chimeric antibodies
What is an arthus reaction?
Localized Type III hypersensitivity reaction
Chron’s is what type of hs reaction?
Type IV
Lupus is what type of hs reaction?
Type III
Poison ivy is what type of hs reaction?
Type IV
Eczema is what type of hs reaction?
Type I
