1.5.3 Anti-Inflammatories Flashcards
Glucocorticoids are derivatives of what?
Cortisol
NSAIDs are inhibitors of?
COX
Glucocorticoids are used when inflammation is associated to what?
Allergic or immune responses
NSAIDs are used for what?
To reduce inflammation, treat pain and reduce fevers
Glucocorticoids have an issue with what?
raising glucose levels
Immunosuppression would call for a glucocorticoid or a NSAID?
glucocorticoid
When glucocorticoids are given for more than 2-4 weeks what happens?
there is feedback suppression of the hypothalamic-pituitary-adrenal (HPA) axis. The longer the drugs are given, the more prolonged the suppression. This is the main reason that glucocorticoids are tapered off whenever long term therapy is used. The body’s normal response to physiologic stress is to release higher than normal amounts of cortisol and epinephrine from the adrenal gland.
Ketorlac and asprin are inhibitors of what?
COX-1
Prednisone and dexamethasone are what?
Synthetic glucocorticoid drugs
celecoxib and diclofenac inhibit what?
COX-2
What can be said about ibuprofen and naproxen?
These inhibit both classes evenly
COX-2 inhibitors tend to have what effect?
typically the thrombotic and hypertensive cardiovascular adverse reactions (even in “healthy” patients) are more common with more selective COX-2 blockade
GI complications are associated with what inhibitors?
COX-1 inhibitors
Inhibition of platelet function and bleeding is a common side effect of what inhibitors?
COX-1
cardiovascular events associated with the COX?-selective inhibitors (i.e. –coxibs) has been attributed to the promotion of platelet aggregation
COX-2
Acetaminophen
Celecoxib, because COX-1 inhibitors can inhibit platelet function and cause further bleeding. This patient is already on an anti-coagulant, and we would not want to exacerbate the patients condition.
Acetaminophen
