Immunity II

Question 1

Lack of response to antigens that is induced by exposure of lymphocytes to these antigens:

Answer 1

immunologic tolerance

Question 2

The ability to discriminate between self and nonself antigens:

Answer 2

immunologic tolerance

Question 3

If immunologic tolerance mechanisms fail:

Answer 3

autoimmunity

Question 4

Normally, microbes are ____ and self-antigens are ____

Answer 4

immunogenic; tolerogenic

Question 5

Developing lymphocytes encounter self antigens in central lymphoid organs:

Answer 5

central tolerance

Question 6

Maturę lymphocytes encounter self antigens in peripheral tissues:

Answer 6

Peripheral tolerance

Question 7

In central T-cell tolerance, what are the two outcomes of self-reactive T-cells?

Answer 7

1. negative selection or deletion
2. development of regulatory T-cells

Question 8

In peripheral T-cells tolerance, ___ block the activation of self-reactive lymphocytes

Answer 8

Regulatory T-cells

Question 9

In peripheral t-cell tolerance, ___ is the functional inactivation of T-cells (lack of costimulation)

Answer 9

anergy

Question 10

In peripheral T-cell tolerance, ______ involves apoptosis of self-reactive lymphocytes

Answer 10

deletion