EXAM 2 QUESTIONS Flashcards
Circulating immune complexes filter out small vessels and activate the complement cascade. C5a attract neutrophils which causes local damaging inflammation….
Type III immune injury disease
All of the following are autoimmune diseases except:
a- systemic lupus
b- burons hypogammaglobulinemia
c- sjogrens syndrome
d- graves disease
(b) bruttons hypogammaglobluinemia
Which organ has very low tolerance to edema?
brain & lungs
Patients with peutz-jegher syndrome often present with:
a- multiple mucosal melanomas
b- nevus flamm
c- peri-oral freckling
d- petechial hemorrhage
(c) peri-oral freckling
T/F: Grading of malignancy is done by pathologists that he microscope. Staging is done by the clinician to determine distribution of tumor in the body
T/T
T/F: A diagnosis of squamous cell carcinoma can be made clinically:
T
Kaposi sarcoma is caused by the HIV:
F (caused by HHV8)
The most common cause of right-sided heart failure is:
Left sided heart failure
(which is caused by CAD, MI, or long-term HTN)
What terminology is used to describe the invagination of the small intestines into itself leading to necrosis?
intussusception
Patients with barretts esophagus are at risk of developing what type of malignancy?
adenocarcinoma (most common in US)
The oral lesions associated with ulcerative colitis are known as:
pyostomatitis vegetans
What terminology used to describe metastasis of an adenocarcinoma to the bilateral ovaries?
Krukernberg tumor
What is the average lifespan of a RBC?
120 days
What radiographic term can be used to describe both sickle cell anemia and thalassemia
Hair on end
Sickle cell anemia occurs due to substitution between which two amino acids?
valine to glutamic acid
Patients with Plummer Vinson syndrome present with which type of anemia?
iron deficient anemia
Which anemia is considered an autoimmune disease?
hemolytic anemia
In viral infections which type of WBC is elevated?
leukocytes
What immune deficiency is caused by having a pronounced decrease in the number of neutrophils?
neutropenia
When presenting with oral manifestation, which leukemia has a predilection of the gingiva?
acute myelogenous leukemia
What low grade lymphoma can be associated with patients with Sjogrens?
MALToma
Which high-grade lymphoma has a predilection for the jawbone of children and is associated with herpes type IV (Epstein Barr)?
Burkett’s Lymphoma
A malignancy of plasma cells is referred to as:
multiple myeloma
Name one medication that impairs ability of platelets to aggregate:
aspirin
T/F: The right lung has two lobes
false (3; the left lung only has 2)
T/F: An aspirated crown is more likely to be lodged in the right side
True
What type of necrosis is seen in TB?
caseous necrosis
What are three types of atelectasis?
- resorption
- compression
- contraction
Which type of emphysema predominates in non-smokers?
paracinar emphysema
What are three different types of lung cancer?
- squamous cell carcinoma
- adenocarcinoma
- small cell carcinoma
What are three different hormones secreted by the anterior pituitary?
FSH
LH
ACTH
TSH
Prolactin
endorphins
Growth Hormone
Excess secretion of growth hormone after epiphyseal plates have closed results in which abnormality?
acromegaly
(if it was before - gigantism)
Which specific portion of the adrenal gland secretes glucocorticoids (cortisol) and is regulated by ACTH?
Zona fasiculata of the adrenal cortex
Which specific portion of the adrenal gland cortex secretes aldosterone and is regulated by angiotensin II?
Zona glomerulosa
Which specific portion of the adrenal cortex secretes androgens and has NO feedback with ACTH?
Zona reticularis
What is the oral manifestation of MEN2B?
mucosal neuromas
Glucagon is secreted by which type of pancreatic cell?
alpha cells
Insulin is secreted by which type of pancreatic cell?
beta cells
T/F: Hep A is considered an STD
True
A 25 year old man present to oral surgery for extraction of #115 with divergence and dilacerated roots. When pt return… cluster of small painful ulcerations that began as vesicles were noted on hard palate. On palpation, this lesions were not indurated and didn’t have roller border.. or symptoms. Which of the following is the most appropriate diagnosis?
recurrent herpetic infection
What immune deficiency is caused by having a pronounced decrease in the # of neutrophils?
Neutropenia
What the name of oral lesion in secondary syphillis?
Mucous patch
Increase of overall size of tissue due to increase in size of cells:
hypertrophy
Name 2 periapical pathosis that can present as a periapical radiolucency associated with a non-vital tooth:
periapical cyst and periapical granuloma
Name the most common benign salivary gland tumor:
pleipmorphic adenoma
Vomiting of fresh red blood:
Hematemesis
Which type of colonic polyp has the greatest incidence of undergoing malignancy?
villous adenoma
The oral lesions associated with ulcerative colitis are known as:
pyostomatitis vegetens
A 60 year old male caries a diagnosis of stable angina pectoris. Which of the following features would you not expect to encounter during the normal, uncomplicated course of this condition?
a- unpredictable spontaneous pain at rest
b- in stable angina- pain is predictable, reproducible, & stable over time
c- it is released by cessation of the event or nitroglycerin
d- variant angina occurs at rest
D- variant angina occurs at rest
Stage 1 HTN is > or =
130/80 mmHg
Stage 2 HTN is > or =
140/90 mmHg
The most common congenital heart defect in humans is:
ventricular septal defect
Granulomatous inflammation occurs in:
crohns disease
Crohns disease can present as:
All of the above
- oral lesions
- thickened intestinal wall
- fistula formation
- low malignancy
- occurs in distal ileum and colon
Ulcerative colitis can present as:
All of the above
- pseudopolyps
- thin intestinal wall
- increased risk of malignancy
Which of the following is NOT associated with MEN 2B?
pituitary tumor
Which of the following IS associated with MEN 2B?
- marfanoid body type
- medullary carcinoma
- adrenal pheochromocytoma
Peutz-Jeghers syndrome is characterized by what type of polyps?
Harmartomatous polyps
Peri oral freckling occurs in what syndrome?
Peutz-Jegher
Macroglossia is caused by:
amyloidosis
Carcinoid tumors secrete what hormones?
serotonin
Krukenberg tumor is found in the:
ovaries
Which is the most common gene translocation for chronic myelogenous leukemia?
T (9:22)
Philadelphia chromosome
T/F: MEN 2A is autosomal dominant and has a mutation on Chr10q protooncogene
True
High risk of cancer in all of the following except:
acanthosis nigricans
Which is not true of in-situ?
has invaded the basement membrane (because in-situ has not yet invaded)
Invagination of the intestine itself:
intussusception
Plummer Vincent is NOT:
pernicious anemia (affects Scandinavian European women, iron deficient anemia, esophageal webs, dysphagia, increased risk of squamous cell carcinoma)
Increased risk of adenocarcinoma?
barrett’s esopaghus
Meckel diverticulum is a developmental defect of:
small intestine (ileum)
Patient has pheochromatoma of adrenal medulla, and nodules in the mouth. What do they have?
MEN 2B
An escape of blood is called:
hemmorhage
Which of the following is true about congestive heart failure:
right sided is caused by left sided
Chronic congestive liver disease is accused by:
right sided heart failure
Which of the following does NOT result from MI?
angina
Infection of the blood:
septicemia
Complete loss of blood supply to the organ:
infarct
Major contributor of osmotic colloid pressure?
albumin
Edema present in right side heart failure:
pitting edema
Organ that edema is NOT tolerated in:
brain
Hemorrhage into skin and mucosa sizes:
petechia< purpura < ecchymosis
Unwanted blood clot:
thrombus
Thrombi on heart valves:
vegetations
Dislodgment and travel of thrombus:
embolism
Virchows triad does not include:
epithelium
( It DOES include endothelial injury, stasis or turbulent blood flow, and hypercoagulability)
T/F: Sarcomas travel by hematogenous route and end in the lungs. Carcinomas travel via lymphatics and end up in the lymph nodes.
T/T
Most common tumor of the lungs:
Metastatic
Which has the alpha 1 anti-trypsin deficiency:
panacinar emphysema
Loss of sympathetic innervation (aka Horners) causes all of the following except:
exopthalmia
Which is most likely to metastasize:
squamous cell carcioma
Surfactant is secreted by:
Type II pneumocytes
What type of collapsed lung is caused by obstruction of the airway:
Resorption
What type of collapsed lung is caused by fluid within the pleural cavity?
compression
What type of collapsed lung is caused by local or generalized fibrotic changes?
Contraction
COPD consists of:
chronic bronchitis and emphysema
T/F: Mesothelioma is a benign outgrowth of pleura. It with decreases with asbestos exposure.
F/F
Most pain receptors are on the:
pleura of lungs
T/F: Grading is done by a pathologist, staging is done by a clinician.
T/T
You can diagnose squamous cell carcinoma clinically:
false
Which present with granulomatous inflammation?
Crohn’s disease
Which is most likely to metastasize?
Squamous cell carcinoma
Carcinoid tumor releases what hormone?
serotonin
Complete loss of blood supply that leads to necrosis:
infarct
Which of the following does not result from myocardial infarction?
angina
Which of the following is NOT commonly associated with fixed stenosis?
Necrosis
Which of the following is NOT a cause of MI?
aneurysm
Which of the following is the most common congenital heart defect?
VSD
Which of the following is not true about infective endocarditis?
Viral infection
Invagination of the small intestine on itself:
Intussussception
Chronic congestive liver disease is caused by:
Right sided heart failure
Krukenberg tumor is found on the:
ovaries
Which of the following is NOT a risk factor for atherosclerosis?
aneurysm
Granulomatous inflammation occurs in:
crohns disease
Crohns disease can present as:
a- oral lesions
b- thickened intestinal wall
c- fistula formation
d- low malignancy
e- occurs in distal ileum and colon
f- all of the above
f- all of the above
Ulcerative colitis can present as
a- pseudopolyps
b- thin intestinal wall
c- increased risk of malignancy
d- pyostomatitis vegetens
e- all of the above
e- all of the above
Which of the following is NOT associated with MEN-2B?
a- intraoral mucosal neuromas
b- thyroid tumor
c- pituitary tumor
d- tumor of the adrenal medulla (adrenal pheochromocytoma)
C- Pituitary tumor (NOT ASSOCIATED)
Type of polyps seen in peutz-jegher?
Hmaratomatous polyps
What types of polyps are seen in Gardner syndrome?
adenomatous polyps
Patient with downward slanting palpebral fissures, Colomba of lower eye lid, and hypo plastic zygoma:
mandibulofacial dysplasia (teacher collins)
Keloid is made of:
collagen
Which of the following is due to defect in fibrilllin?
Marfan syndrome
Which of the following expresses asymmetry?
Parry romberg
Peri-oral freckling occurs in what syndrome?
peutz- Jegher
Signs of Pierre robin
a- mandibular hypoplasia
b- palatal cleft
c- glossoptosis
d- all of the above
d- all of the above
Macroglossia is caused by:
amyloidosis
What type of collapsed lung is caused by obstruction of the airway?
resorption
What type of collapsed lung is caused by fluid within the pleural cavity?
compression
What type of collapsed lung is caused by local or generalized fibrotic changes?
contraction
COPD:
emphysema and chronic bronchitis
Plummer Vincent is NOT:
pernicious anemia (autoimmune atrophic gastritis)
Most pain receptors are on the:
pleura of the lungs
Patient has pheocytochromatoma of the adrenal medulla and nodules in the mouth: What do they have?
Men IIB
Head and neck malignancy:
Gardner syndrome
Yellowing of gingiva:
jaundice
Hard palate?
PLGA- polymorphous low grade adenocarcinoma- a rare tumor of minor salivary glands; often hard palate involvement
Hashimotos thyroiditis at risk for:
non-hodgkin lympohma
A 55 year old with swollen gingiva and bruising:
AML
What does not have to do with HYPER pituitary hormones?
Sheehan syndrome (this is necrosis of pituitary gland = hypo- after delivery of kid)
What is co-associated with Hep D?
Hep B
T/F: Mesothelioma is a BENIGN outgrowth of the pleura. It DECREASES with asbestos exposure.
F/F (malignant & increases)
Meckel diverticulum is a developmental defect of the:
small intestine (ileum)
Barrett’s esophagus causes an increased risk for:
increased risk of adenocarcinoma
H. pylori can be involved with all of the following except:
a- squamous cell carcinoma
b- chronic gastritis
c- peptic ulcer disease
d- gastic adenocarcioma
e- gastric MALT lymphoma
A- squamous cell carcinoma (has nothing to do with h. pylori)
Which has the alpha-1 anti-trypsin deficiency?
panacinar emphysema
Which disease has an autoimmune component?
a- pernicious anemia
b- sickle cell anemia
c- folic acid
d- iron deficiency
a- pernicious anemia
diminished vitamin b12 absorption
Life span of RBC:
4 months (120 days)
Hair on end radiographic appearance?
Thalassemia? Sickle cell trait?
Most common anemia:
iron deficiency
CML gene translocation:
9:22
Step ladder:
sickle cell anemia
Sjogrens syndrome is associated with which lymphoma?
MALT-oma
sjogrens- a chronic long-lasting autoimmune disorder that happens when immune system attacks the glands that make moisture in the eyes, mouth, and other parts of the body
Insulin is produced by what type of cell?
beta cell (in islets of langerhans)
Thrombocytopenia purpura platelet count would be:
too little
Multiple myeloma appears radiographically as:
punched out radiolucency
Most common leukemia in children?
ALL
Pheochromocytoma and mucosal neuromas =
MEN 2B
Universal donor blood type?
O
Chipmunk face for thalassemia is due to:
compensatory HyperPLASIA of bone marrow
Kid regularly has although ulcerations on the tongue, chronic gingivitis, and bone loss:
cyclic neutropenia
surfactant is secreted by:
Type II pneumocytes
Histologically similar to parotid:
Acinic cell carcinoma
Histologically kooks like Swiss cheese:
adenoid cystic carcinoma (poor long-term prognosis)
Histologically a mixture of ductal and my-epithelial elements:
pleomorphic adenoma
Most common benign salivary gland tumor:
pleomorphic adenoma
Most common malignant salivary gland tumor:
mucoepidermoid carcinoma
Salivary gland tumor that favors the hard palate:
polymorphous low grade adenocarcinoma
Upper lip tumor:
monomorphic adenoma
Most likely to be in the parotid gland?
papillary cyst adenoma lymphomatous