Granulation Tissue Vs. Granulomatous Tissue Flashcards
Is the tissue that repairs wounds
granulation tissue
Describe granulation tissue:
It is highly vascular and when viewed with the naked eye is red and granular
In granulation tissue, what serves as the scaffolding for endothelial cells and fibroblasts that grow into the clot from the wound margin?
fibrin strands
In granulation tissue, the wound fills with a blood clot and the fibrin strands in the clot serve as scaffolding for ___ and ____ that grow into the clot from the wound margin.
endothelial cells & fibroblasts
In granulation tissue, endothelium forms new ____ and fibroblasts makes new ___ that restores ___
vascular channels; collagen; tensile strength
What are the two main cell types in granulation tissue?
- endothelial cells
- fibroblasts
What is the terminal event in injury/inflammatory lesion?
repair
What would happen to wounds with out granulation tissue?
wounds would not heal
Granulation tissue may overgrow and form an unwelcome mass called a:
pyogenic granuloma
A pyogenic granuloma can simply be considered:
granulation tissue (too much of a good thing)
An abscessed tooth left untreated may develop a mass of chronically inflamed granulation tissue at the root tip called a:
periapical dental granuloma
This is a photo of ____. What do the red areas represent?
granulation tissue; newly formed vascular channels
This image shows a ____, which is an overgrowth of ____.
pyogenic granuloma; inflamed granulation tissue
A persistent growth of inflamed granulation tissue at the apex of a tooth with a necrotic pulp:
periapical dental granuloma
Tissue that contains granulomas:
granulomatous tissue
A collection of macrophages, a few lymphocytes, and a surrounding this collar of fibroblasts:
granuloma
macrophages in a granuloma may also be called:
epihtelioid histiocytes
Granulomas may or may not have:
multinucleated giant cells
In granulomatous tissue, if nuclei are arranged in a radial pattern (horseshoe or necklace), it is a:
Langhan’s Giant Cell
In granulomatous tissue, if nuclei are randomly arranged in the cytoplasm, this is a:
foreign body type giant cell
Most injuries and infections provoke ____, a vascular response that displays the cardinal signs of inflammation (rubor, calor, dolor, and tumor)
exudative inflammation
A limited group of noxious agents (microbes and foreign material) do not provoke ____ but instead they cause the formation of ____.
exudative inflammation; granulomas
A limited group of noxious agents (microbes and foreign material) do not provoke exudative inflammation but instead they cause the formation of granulomas and this response is known as;
granulomatous inflammation
Lacking redness, swelling, and pain, _____ are always chronic and may be silent for weeks to months before symptoms arise.
granulomatous diseases
_____ is the mother of all infectious granulomatous diseases; ___ is another example.
tuberculosis; leprosy
In tuberculosis, the granulomas characteristically exhibit a pattern of necrosis referred to as ____ , therefore the term ____.
caseous (cheese-like) necrosis; caseating granulomas
What can be seen in this high-power image? How do you know?
langhan’s giant cell; radial (horseshoe) arrangement of nuclei
What can be seen in this medium-power image? How do you know?
several foreign body giant cells; random arrangement of nuclei in cytoplasm
A focal collection of epithelioid histiocytes with a sprinkling of lymphocytes, maybe one or more multinucleated giant cells and a thin collar of fibroblasts surrounding them all:
granuloma
